Overview of Immune system; Human Immune system: Effectors of immune system; Innate & Adaptive Immunity; Activation of the Innate Immunity; Adaptive Immunity; T and B cells in adaptive immunity; Immune response in infection; Correlates of protection.

UNIT III:                                                 8 Hrs

Vaccination and immune response; Adjuvants in Vaccination; Modulation of immune responses: Induction of Th1 and Th2 responses by using appropriate adjuvants and antigen delivery systems - Microbial adjuvants, Liposomal and Microparticles as delivery systems; Chemokines and cytokines; Role of soluble mediators in vaccination; Oral immunization and Mucosal Immunity.

Protective immune response in bacterial; viral and parasitic infections; Primary and Secondary immune responses during infection; Antigen presentation and Role of Antigen presenting cells: Dendritic cells in immune response; Innate immune response; Humoral (antibody mediated) responses; Cell mediated responses: role of CD4+ and CD8+ T cells; Memory responses: Memory and effector T and B cells, Generation and Maintenance of memory T and B cells.

Vaccination and immune response; Adjuvants in Vaccination; Modulation of immune responses: Induction of Th1 and Th2 responses by using appropriate adjuvants and antigen delivery systems - Microbial adjuvants, Liposomal and Microparticles as delivery systems; Chemokines and cytokines; Role of soluble mediators in vaccination; Oral immunization and Mucosal Immunity.

History of vaccines, Conventional vaccines; Bacterial vaccines; Viral Vaccines; Vaccines based on routes of administration: parenteral, oral, mucosal; Live attenuated and inactivated vaccine; SubUnit Vaccines and Toxoids; Peptide Vaccine.

New Vaccine Technologies; Rationally designed Vaccines; DNA Vaccination; Mucosal vaccination; New approaches for vaccine delivery; Engineering virus vectors for vaccination; Vaccines for targeted delivery (Vaccine Delivery systems); Disease specific vaccine design: Tuberculosis Vaccine; Malaria Vaccine; HIV/AIDS vaccine; New emerging diseases and vaccine needs (Ebola, Zika).