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GENETICS [1]

Paper Code: 
BTE 221
Credits: 
5
Contact Hours: 
75
Objective: 

Course Outcomes (COs):

              

          Course Outcomes

Learning and teaching strategies

Assessment Strategies

  
 

Upon completion of the course the learner will:

CO 42: Understand the basic principles of genetics

CO 43: Differentiate, compare and contrast different types of gene interactions and  predict the outcomes of these interactions.

CO 44: Analyse the different types sex determination mechanisms and the role of sex linked genes in inheritance.

CO 45: Apply the knowledge of linkage and recombination mechanisms to construct genetic maps.

CO 46: Evaluate the molecular basis of mutations and repair mechanisms.

CO 47: Evaluate the processes that cause changes in the kind and amount of genetic variation in populations.

CO 48: Understand extrachromosomal inheritance and Hardy Weinberg equilibrium.

Interactive Lectures,

Discussion,

Tutorials, Demonstrations,

Assignments

Reading Journals

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects

  
 

 

 

15.00
Unit I: 
Classical Genetics & Gene interactions
  • Mendel's experiments, Monohybrid, Dihybrid and Tri-hybrid ratios, Dominance and Recessive Factors, Law of segregation, Laws of independent assortment, Test cross and Back cross.
  • Allelic and non-allelic interactions.
  • Inheritance of quantitative traits-additive effect-skin color in man.

 

 

 

 

13.00
Unit II: 
Sex Determination and sex linked inheritance
  • Mechanism of Sex determination in Drosophila, Birds, Man, Grasshoppers, Honey bees and plants. Environmental sex determination. Chromosome theory of heredity, Non disjunction, Dosage compensation Mechanisms: Hyperactivation, inactivation and hypoactivation.
  • pattern of inheritance of sex-linked genes, X and Y-linked inheritance and their examples.

 

 

15.00
Unit III: 
Concept of the gene & recombination mechanisms
  • Gene: unit of structure & function, complementation test.
  • Linkage, Gene mapping with recombination frequencies. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.

 

17.00
Unit IV: 
Gene Mutations & Chromosomal aberrations
  • Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test.
  • DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases.
  • Chromosomal aberrations- changes in chromosome structure & number, inherited disorders.

 

15.00
Unit V: 
Extra-cytoplasmic inheritance & Population Genetics
  • Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects.
  • Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law, Introduction to QTLs.

 

ESSENTIAL READINGS: 

ESSENTIAL READINGS:

  • Genetics, conceptual approach, Benjamin A Pierce, 7th edition, W. H. Freeman and Company, 2019
  • Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S.  9th edition, W. H. Freeman and Company, 2007.
  • Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ : John Wiley & Sons, Inc., 2017
  • Microbial Genetics, Stanly R Maloy, John E Cronan Jr. and David Freifelder. 2nd edition, Narosa publishing house, New Delhi. 2006.
  • iGenetics- A Molecular Approach, Russell PJ., 3rd edition, Benjamin Cummings. 2009.

SUGGESTED READINGS:

  • Molecular Genetics of Bacteria, Larry Snyder, Joseph E. Peters, Tina M. Henkin, Wendy Champness, 4th edition, American Society for Microbiology, Washington. 2013.
  • Principles of Genetics, (7th edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2015
  • Genetics, (3rd edition), M V Strickberger, New Delhi : PHI Learning, 2012
  • Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
  • Human Genetics: Concepts and Applications, (10th edition), R Lewis, WCB McGraw Hill, USA, 2011.
  • Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000
  • Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones,  Jones and Barlett Publishers, Massachusetts, USA, 1998.          

 

 

REFERENCES: 

e RESOURCES:

JOURNALS:

  • Journal of Genetics
  • Frontiers in Genetics
  • Environmental and molecular mutagenesis
  • Nature Genetics
  • Genetics Research

 

 

 

Academic Year: 
2022-2023 [8]

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Source URL: https://biotech.iisuniv.ac.in/courses/subjects/genetics-9

Links:
[1] https://biotech.iisuniv.ac.in/courses/subjects/genetics-9
[2] https://doi.org/10.1007/978-1-4615-8966-2_1
[3] https://ommbid.mhmedical.com/content.aspx?bookid=2709&sectionid=225072020
[4] https://doi.org/10.1002/em.22087
[5] https://www.nature.com/scitable/knowledge/library/the-hardy-weinberg-principle-13235724/
[6] https://www.youtube.com/watch?v=xPkOAnK20kw
[7] https://doi.org/10.3389/fgene.2020.00210
[8] https://biotech.iisuniv.ac.in/academic-year/2022-2023