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GENETICS
Course Outcomes (COs):
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Course Outcomes |
Learning and teaching strategies |
Assessment Strategies |
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Upon completion of the course the learner will: CO 42: Understand the basic principles of genetics CO 43: Differentiate, compare and contrast different types of gene interactions and predict the outcomes of these interactions. CO 44: Analyse the different types sex determination mechanisms and the role of sex linked genes in inheritance. CO 45: Apply the knowledge of linkage and recombination mechanisms to construct genetic maps. CO 46: Evaluate the molecular basis of mutations and repair mechanisms. CO 47: Evaluate the processes that cause changes in the kind and amount of genetic variation in populations. CO 48: Understand extrachromosomal inheritance and Hardy Weinberg equilibrium. |
Interactive Lectures, Discussion, Tutorials, Demonstrations, Assignments Reading Journals |
Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects |
- Mendel's experiments, Monohybrid, Dihybrid and Tri-hybrid ratios, Dominance and Recessive Factors, Law of segregation, Laws of independent assortment, Test cross and Back cross.
- Allelic and non-allelic interactions.
- Inheritance of quantitative traits-additive effect-skin color in man.
- Mechanism of Sex determination in Drosophila, Birds, Man, Grasshoppers, Honey bees and plants. Environmental sex determination. Chromosome theory of heredity, Non disjunction, Dosage compensation Mechanisms: Hyperactivation, inactivation and hypoactivation.
- pattern of inheritance of sex-linked genes, X and Y-linked inheritance and their examples.
- Gene: unit of structure & function, complementation test.
- Linkage, Gene mapping with recombination frequencies. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.
- Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test.
- DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases.
- Chromosomal aberrations- changes in chromosome structure & number, inherited disorders.
- Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects.
- Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law, Introduction to QTLs.
ESSENTIAL READINGS:
- Genetics, conceptual approach, Benjamin A Pierce, 7th edition, W. H. Freeman and Company, 2019
- Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S. 9th edition, W. H. Freeman and Company, 2007.
- Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ : John Wiley & Sons, Inc., 2017
- Microbial Genetics, Stanly R Maloy, John E Cronan Jr. and David Freifelder. 2nd edition, Narosa publishing house, New Delhi. 2006.
- iGenetics- A Molecular Approach, Russell PJ., 3rd edition, Benjamin Cummings. 2009.
SUGGESTED READINGS:
- Molecular Genetics of Bacteria, Larry Snyder, Joseph E. Peters, Tina M. Henkin, Wendy Champness, 4th edition, American Society for Microbiology, Washington. 2013.
- Principles of Genetics, (7th edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2015
- Genetics, (3rd edition), M V Strickberger, New Delhi : PHI Learning, 2012
- Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
- Human Genetics: Concepts and Applications, (10th edition), R Lewis, WCB McGraw Hill, USA, 2011.
- Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000
- Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones, Jones and Barlett Publishers, Massachusetts, USA, 1998.
e RESOURCES:
- Freese E. (1971) Molecular Mechanisms of Mutations. In: Hollaender A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8966-2_1
- Clancy, S. (2008) Genetic mutation. Nature Education 1(1):187
- Antonarakis S.E., & Krawczak M, & Cooper D.N. (2019). The nature and mechanisms of human gene mutation. Valle D.L., & Antonarakis S, & Ballabio A, & Beaudet A.L., & Mitchell G.A.(Eds.), The Online Metabolic and Molecular Bases of Inherited Disease. McGrawHill. https://ommbid.mhmedical.com/content.aspx?bookid=2709§ionid=225072020
- Chatterjee, N., & Walker, G. C. (2017). Mechanisms of DNA damage, repair, and mutagenesis. Environmental and molecular mutagenesis, 58(5), 235–263. https://doi.org/10.1002/em.22087
- https://www.nature.com/scitable/knowledge/library/the-hardy-weinberg-principle-13235724/
- https://www.youtube.com/watch?v=xPkOAnK20kw
- Front. Genet., 13 March 2020 | https://doi.org/10.3389/fgene.2020.00210
JOURNALS:
- Journal of Genetics
- Frontiers in Genetics
- Environmental and molecular mutagenesis
- Nature Genetics
- Genetics Research
