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GENETICS [1]

Paper Code: 
BTE 301
Credits: 
3
Contact Hours: 
45
Objective: 

Upon completion of the course the learner will:

CO 31: Understand the different types of gene interactions and predict the outcomes of different genetic crosses.

CO 32: Identify the different types sex determination mechanisms and sex-linked inheritance.

CO 33: Analyse the relationship between linkage and recombination frequencies for mapping.

CO 34: Evaluate the different methods of recombination in prokaryotes

CO 35: Analyse the molecular basis of mutations

CO 36: Understand extrachromosomal inheritance and Hardy Weinberg equilibrium. 

9.00
Unit I: 
Mendelian genetics
  • Mendelian genetics-Mendel’s Experiment and Laws of inheritance, Gene interactions-co dominance and incomplete dominance Epistasis (recessive and dominant), Complementary and Supplementary genes, Lethal genes.

 

9.00
Unit II: 
Sex determination &sex linked inheritance
  • Sex determination mechanisms in plants and animals. Non-disjunction and Genetic balance theory, Sex chromatin bodies and Dosage compensation, Sex linked inheritance.

 

 

9.00
Unit III: 
Linkage, Recombination & Genetic system
  • Linkage and mapping genes, CIS-TRANS or complementation test for functional allelism.
  • Recombination in bacteria-conjugation, transformation and transduction.

 

 

10.00
Unit IV: 
Mutations
  • Spontaneous and induced mutations, types of point mutations, physical and chemical mutagens. Structural and numerical chromosomal aberrations.
  • Evolution of wheat, cotton and Raphanobrassica.  Hereditary defects in humans-Downs syndrome, Klinfelters syndrome and Turners syndrome.

 

 

8.00
Unit V: 
Extra chromosomal inheritance & population genetics
  • Extra chromosomal inheritance, maternal effect, chloroplast and mitochondrial genetic system.
  • Population genetics-gene and genotype frequency, Hardy-Weinberg equilibrium.

 

 

ESSENTIAL READINGS: 
  • Microbial Genetics, Stanly R Maloy, John E Cronan Jr. and David Freifelder. 2nd edition, Narosa publishing house, New Delhi. 2006.
  • Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
  • Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S.  9th edition, W. H. Freeman and Company, 2007.
  • Advanced Genetics, G S Miglani, Narosa Publishing House Pvt. Ltd., New Delhi, 2007
  • Genetics, (3rd edition), M V Strickberger, New Delhi : PHI Learning, 2012

 

REFERENCES: 

 

SUGGESTED READINGS:

  • Fundamental Genetics, J Ringo, Cambridge University Press, 2004
  • Lewin’s Gene XII, Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick, 12th edition Jones and Bartlett Publishers, Inc, 2017
  • Cell Biology & Molecular Biology, 8th edition, E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2017
  • Genetics- A Molecular Approach, Russell PJ., 3rd edition, Benjamin Cummings. 2009.
  • Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ: John Wiley & Sons, Inc., 2017

 

e RESOURCES:

  • Hake, L. & O'Connor, C. (2008) Genetic mechanisms of sex determination. Nature Education 1(1):25
  • Saccone, G., Pane, A., &Polito, L. C. Sex determination in flies, fruit flies and butterflies. Genetica 116, 15–23 (2002)
  • Miko, I. (2008) Gregor Mendel and the principles of inheritance. Nature Education 1(1):134
  • Clancy, S. (2008) Genetic mutation. Nature Education 1(1):18
  • Andrews, C. (2010) The Hardy-Weinberg Principle. Nature Education Knowledge 3(10):65
  • https://doi.org/10.1016/B978-0-12-374984-0.00996-7 [2]

 

JOURNALS:

  • Journal of Genetics
  • Frontiers in Genetics

 

 

Academic Year: 
2022-2023 [3]

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Source URL: https://biotech.iisuniv.ac.in/courses/subjects/genetics-11

Links:
[1] https://biotech.iisuniv.ac.in/courses/subjects/genetics-11
[2] https://doi.org/10.1016/B978-0-12-374984-0.00996-7
[3] https://biotech.iisuniv.ac.in/academic-year/2022-2023