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GENETICS
Paper Code:
BTE 301
Credits:
3
Contact Hours:
45
Objective:
Upon completion of the course the learner will:
CO 31: Understand the different types of gene interactions and predict the outcomes of different genetic crosses.
CO 32: Identify the different types sex determination mechanisms and sex-linked inheritance.
CO 33: Analyse the relationship between linkage and recombination frequencies for mapping.
CO 34: Evaluate the different methods of recombination in prokaryotes
CO 35: Analyse the molecular basis of mutations
CO 36: Understand extrachromosomal inheritance and Hardy Weinberg equilibrium.
9.00
Unit I:
Mendelian genetics
- Mendelian genetics-Mendel’s Experiment and Laws of inheritance, Gene interactions-co dominance and incomplete dominance Epistasis (recessive and dominant), Complementary and Supplementary genes, Lethal genes.
9.00
Unit II:
Sex determination &sex linked inheritance
- Sex determination mechanisms in plants and animals. Non-disjunction and Genetic balance theory, Sex chromatin bodies and Dosage compensation, Sex linked inheritance.
9.00
Unit III:
Linkage, Recombination & Genetic system
- Linkage and mapping genes, CIS-TRANS or complementation test for functional allelism.
- Recombination in bacteria-conjugation, transformation and transduction.
10.00
Unit IV:
Mutations
- Spontaneous and induced mutations, types of point mutations, physical and chemical mutagens. Structural and numerical chromosomal aberrations.
- Evolution of wheat, cotton and Raphanobrassica. Hereditary defects in humans-Downs syndrome, Klinfelters syndrome and Turners syndrome.
8.00
Unit V:
Extra chromosomal inheritance & population genetics
- Extra chromosomal inheritance, maternal effect, chloroplast and mitochondrial genetic system.
- Population genetics-gene and genotype frequency, Hardy-Weinberg equilibrium.
ESSENTIAL READINGS:
- Microbial Genetics, Stanly R Maloy, John E Cronan Jr. and David Freifelder. 2nd edition, Narosa publishing house, New Delhi. 2006.
- Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
- Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S. 9th edition, W. H. Freeman and Company, 2007.
- Advanced Genetics, G S Miglani, Narosa Publishing House Pvt. Ltd., New Delhi, 2007
- Genetics, (3rd edition), M V Strickberger, New Delhi : PHI Learning, 2012
REFERENCES:
SUGGESTED READINGS:
- Fundamental Genetics, J Ringo, Cambridge University Press, 2004
- Lewin’s Gene XII, Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick, 12th edition Jones and Bartlett Publishers, Inc, 2017
- Cell Biology & Molecular Biology, 8th edition, E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2017
- Genetics- A Molecular Approach, Russell PJ., 3rd edition, Benjamin Cummings. 2009.
- Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ: John Wiley & Sons, Inc., 2017
e RESOURCES:
- Hake, L. & O'Connor, C. (2008) Genetic mechanisms of sex determination. Nature Education 1(1):25
- Saccone, G., Pane, A., &Polito, L. C. Sex determination in flies, fruit flies and butterflies. Genetica 116, 15–23 (2002)
- Miko, I. (2008) Gregor Mendel and the principles of inheritance. Nature Education 1(1):134
- Clancy, S. (2008) Genetic mutation. Nature Education 1(1):18
- Andrews, C. (2010) The Hardy-Weinberg Principle. Nature Education Knowledge 3(10):65
- https://doi.org/10.1016/B978-0-12-374984-0.00996-7
JOURNALS:
- Journal of Genetics
- Frontiers in Genetics
Academic Year:
