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GENETICS
to enable students to-
- Study the classical genetics & gene interactions.
- Learn the mechanism of sex linked inheritance and sex determination.
- Understand concept of gene, linkage, crossing over& recombination mechanisms.
- Understand gene mutations and chromosomal aberrations.
- Learn about extracytoplasmic inheritance & population genetics.
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Course |
Learning outcome (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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BTE 221
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Genetics
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Upon completion of the course students will be able to: CO 28: Assess classical genetics CO 29: Analyze mechanism of sex determination and sex-linked inheritance CO 30: Evaluate concept of gene and recombination mechanisms CO 31: Compare and contrast gene mutations and chromosomal aberrations CO 32: Assess extracytoplasmic inheritance and population genetics |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments Learning activities for the students: Self learning assignments, Effective questions, Giving tasks |
Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation |
Mendel's experiments Monohybrid ratios-Dominance and Recessive factors Laws of segregation - Dihybrid and Tri hybrid ratios - Laws of independent assortments - Test cross and Back cross. Allelic and non-allelic interactions.
Inheritance of quantitative traits-additive effect-skin color in man.
Mechanism of Sex determination in Drosophila, Birds, Man, hymenopterans, environmental factors & sex determination.
X-linked inheritance, pattern of inheritance of sex linked genes, sex linkage in
Drosophila, X-linked traits in humans.
Gene: unit of structure & function, complementation test.
Linkage & crossing over. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.
Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test.
DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases.
Chromosomal aberrations- changes in chromosome structure & number, inherited disorders
Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects.
Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law.
- Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones, Jones and Barlett Publishers, Massachusetts, USA, 1998
- Human Genetics: Concepts and Applications, (2nd edition), R Lewis, WCB McGraw Hill, USA, 1997.
- Microbial Genetics, (2nd edition), Maloy, D Freidfelder and John E Cronan., Jones and Barlett Publishers, 1994
- Molecular genetics: An introductory narrative, (2nd edition), G S Stent and R Calendar, CBS Publishers and distributors, 2002
- Principles of Genetics, (8th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2005
- The Science of Genetics, Atherly, Girton, and McDonald ,Saunders College Publishing, Fort Worth, USA, 1999
- Advanced Genetics, G S Miglani, Narosa Publication House, 2003
- Cell Biology & Molecular Biology, (8th edition), E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2005
- Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000
- Genetics ,(3rd edition), M V Strickberger, Prentice Hall of India Pvt. Ltd., 2004
- Genetics, (5th edition), P J Russel, The Benjamin/Cummings Publishing Company, USA.,1998
- Principles of Genetics, (2nd edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2000
