Immunology

Paper Code: 
MBL 223
Credits: 
05
Contact Hours: 
75
Objective: 

To enable students to- • understand the various cells involved in Immune system. • learn the cellular and molecular aspects of Immune system. • study about the regulation of Immune response and Antigen – Antibody reactions. • learn about the applied aspects of Immunology.

15.00
Unit I: 
Introduction to immune system

Basic Immunology: - Phylogeny of immune system, Innate and acquired immunity, Clonal nature of immune response. Cells of the Immune system: Hematopoiesis and differentiation, Lymphocyte trafficking, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK and Lymphokine activated killer cells, Eosinophils, Neutrophils and Mast Cells. Organization and structure of lymphoid organs

15.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens. Immunoglobulin: structure, types and their function, Major histocompatibility complex, B-Cell Receptor and T-Cell Receptor, generation and diversity, Complement system

18.00
Unit III: 
Immune response & its regulation

Antigen processing and presentation, generation of Humoral and Cell mediated immune responses, B- and T- cell maturation, activation and differentiation, Cytokines and their role in immune regulation, T-cell regulation, MHC restriction, Immunological tolerance, Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity

12.00
Unit IV: 
Antigen- antibody interactions

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

15.00
Unit V: 
Advanced concepts in Immunology

Hypersensivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity of infectious agents (intracellular parasites, helminthes and viruses), Tumor Immunology, AIDS and other immunodeficiencies, Hybridoma Technology and Monoclonal antibodies.

ESSENTIAL READINGS: 

1. Kuby’s Immunology, (4th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York. 2. Roitt’s Essential Immunology,(10th edition), Ivan M .Roitt and Peter J. Delves, Blackwell Science, 2001 3. Instant Notes on Immunology, (2nd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003

REFERENCES: 

4. Cellular and Molecular Immunology, (3rd edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 1998 5. Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001 6. Medical Microbiology and Immunology: Examination and Board Review, (7th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002

Academic Year: 
2018-2019
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