Genetics

Paper Code: 
BTE 221
Credits: 
5
Contact Hours: 
75
Objective: 

to enable students to-

  • Study the classical genetics & gene interactions.
  • Learn the mechanism of sex linked inheritance and sex determination.
  • Understand concept of gene, linkage, crossing over& recombination mechanisms.
  • Understand gene mutations and chromosomal aberrations.
  • Learn about extracytoplasmic inheritance & population genetics.
15.00
Unit I: 
Classical Genetics & Gene interactions

Mendel's experiments Monohybrid ratios-Dominance and Recessive factors Laws of segregation - Dihybrid and Tri hybrid ratios - Laws of independent assortments - Test cross and Back cross. Allelic and non-allelic interactions. Inheritance of quantitative traits-additive effect-skin color in man.

13.00
Unit II: 
Sex Determination and sex linked inheritance

Mechanism of Sex determination in Drosophila, Birds, Man, hymenopterans, environmental factors & sex determination. X-linked inheritance, pattern of inheritance of sex linked genes, sex linkage in Drosophila, X-linked traits in humans.

15.00
Unit III: 
Concept of the gene & recombination mechanisms.

Gene: unit of structure & function, complementation test. Linkage & crossing over. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.

17.00
Unit IV: 
Gene Mutations & Chromosomal aberrations.

Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test. DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases. Chromosomal aberrations- changes in chromosome structure & number, inherited disorders.

15.00
Unit V: 
Extracytoplasmic inheritance & Population Genetics

Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects. Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law.

ESSENTIAL READINGS: 

1. Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones, Jones and Barlett Publishers, Massachusetts, USA, 1998 2. Human Genetics: Concepts and Applications, (2nd edition), R Lewis, WCB McGraw Hill, USA, 1997. 3. Microbial Genetics, (2nd edition), Maloy, D Freidfelder and John E Cronan., Jones and Barlett Publishers, 1994 4. Molecular genetics: An introductory narrative, (2nd edition), G S Stent and R Calendar, CBS Publishers and distributors, 2002 5. Principles of Genetics, (8th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2005 6. The Science of Genetics, Atherly, Girton, and McDonald ,Saunders College Publishing, Fort Worth, USA, 1999

REFERENCES: 

1. Advanced Genetics, G S Miglani, Narosa Publication House, 2003 2. Cell Biology & Molecular Biology, (8th edition), E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2005 3. Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000 4. Genetics ,(3rd edition), M V Strickberger, Prentice Hall of India Pvt. Ltd., 2004 5. Genetics, (5th edition), P J Russel, The Benjamin/Cummings Publishing Company, USA.,1998 6. Principles of Genetics, (2nd edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2000

Academic Year: 
2018-2019
  • Printer-friendly version
  • PDF version