Biostatistics and Bioinformatics

Paper Code: 
AMB 602
Credits: 
03
Contact Hours: 
45
Objective: 

 

This paper will enable students to-
  • Understand the importance of statistical analysis of biological data
  • Learn various methods of statistical analysis
  • Get aquatinted to the computational aspect of Biotechnology
8.00
Unit I: 
Basics of Biostatistics

Sampling - Sampling procedure, types of sampling, Classification and tabulation of data, frequency distribution, probability, addition and multiplication theorem of probability.

9.00
Unit II: 
Measure of central tendency and dispersion

Mean, median and mode, Measures of dispersion - range, mean deviation, standard deviation, coefficient of variation.

10.00
Unit III: 
Test of significance

Hypothesis testing, Nulls hypothesis and alternative hypothesis, Chi-square test, F-test, ANOVA-A one way and two way classification.

9.00
Unit IV: 
Overview of Bioinformatics

Overview of bioinformatics- introduction, Database types- Primary and secondary databases, sequence databases- nucleotide and protein sequence databases (NCBI, EMBL, DDBJ, UNIPORT), Structure databases (PDB, MMDB)

9.00
Unit V: 
Sequence similarity searching

Concept of similarity searching, methods of similarity searching (BLAST, FASTA), application of similarity searching in gene identification and functional assignment, Information retrieval from biological databases

ESSENTIAL READINGS: 

 

1. Fundamentals of Biostatistics, Khan,  Publishing Corporation, 1999
2. Statistical Methods in Biology, 3rd edition, N T J Bailey, Cambridge University Press, 1995
3. Statistics for Biologist, R C Campbell, Cambridge University Press, 1989
REFERENCES: 

 

1. Bioinformatics, Higgins & Taylor, OUP, 2000
2. Biostatistics: A Foundation for Analysis in Health Sciences, 6th edition, W W Daniel, John Wiley and Sons Inc., 1995 
3. Introduction to Bioinformatics, A Teresa and D P Smith, Prentice Hall Publisher, 1999
4. Molecular databases for Protein Sequence and Structure Studies, J A Sillince and M Sillince, Springer Verlag, 1991
5. Practical statistics for Experimental Biologists, A C Swardlaw,  John Wiley and sons Inc., 1985
6. Sequence analysis primer, Gribskov and Devereux, Stockton Press, 1989
Academic Year: 
2018-2019
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