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Immunology
Paper Code:
AMB 401
Credits:
03
Contact Hours:
45
Objective:
This paper will enable students to-
- learn the fundamentals of immune system
- study the various cellular and molecular aspects of immune system
- understand the regulation of immune response
- learn various immunological diagnostic techniques
8.00
Unit I:
Basic Immunology
Introduction to immune system- Phylogeny of immune system, Innate and acquired immunity
Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells
Organization and structure of lymphoid organs
11.00
Unit II:
Cellular and molecular aspects
Nature and biology of antigens and super antigens
Immunoglobulin: structure, types and their function
MHC, B and T-Cell Receptor
Complement system
10.00
Unit III:
Immune response & its regulation
Generation of Humoral and Cell mediated immune responses
B- and T- cell maturation, activation and differentiation
Cytokines and their role in immune regulation
T-cell regulation, MHC restriction
Immunological tolerance
7.00
Unit IV:
Antigen- antibody interactions
Antigen processing and presentation
Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence
9.00
Unit V:
Selected concepts in Immunology
Hypersenstivity
Autoimmunity
Tumor Immunology
AIDS and other immunodeficiencies
ESSENTIAL READINGS:
1. Kuby Immunology, 4th edition- R.A. Goldsby and others, Freeman & Co., New York, 2001
2. Roitt’s, Essential Immunology, 10th edition, Ivan M Roitt and Peter J Delves, Blackwell Science, 2001
3. Instant Notes on Immunology, 2nd edition, Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003
REFERENCES:
1. Cellular and Molecular Immunology, 3rd edition, Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
2. Immunology: A Comprehensive Review, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
3. Medical Microbiology and Immunology: Examination and Board Review, 7th edition,Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002
Academic Year:
