GENETICS

Paper Code: 
BTE 221
Credits: 
5
Contact Hours: 
75
Objective: 

·      Study the classical genetics & gene interactions.

·      Learn the mechanism of sex linked inheritance and sex determination.

·      Understand concept of gene, linkage, crossing over& recombination mechanisms.

·      Understand gene mutations and chromosomal aberrations.

·      Learn about extracytoplasmic inheritance & population genetics.

15.00
Unit I: 
Classical Genetics & Gene interactions

 

Mendel's experiments Monohybrid ratios-Dominance and Recessive factors Laws of segregation - Dihybrid and Tri hybrid ratios - Laws of independent assortments - Test cross and Back cross. Allelic and non-allelic interactions.

Inheritance of quantitative traits-additive effect-skin color in man.

 

 

 

 

15.00
Unit II: 
Sex Determination and sex linked inheritance

Mechanism of Sex determination in Drosophila, Birds, Man, hymenopterans, environmental factors & sex determination.

      X-linked inheritance, pattern of inheritance of sex linked genes, sex linkage in

      Drosophila, X-linked traits in humans.

Unit III: 
Concept of the gene & recombination mechanisms.

 

Gene: unit of structure & function, complementation test.

Linkage & crossing over. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.

 

 

 

15.00
Unit IV: 
Gene Mutations & Chromosomal aberrations.

Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test.

DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases.

Chromosomal aberrations- changes in chromosome structure & number, inherited disorders.

15.00
Unit V: 
Extracytoplasmic inheritance & Population Genetics

 

Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects.

Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law.

ESSENTIAL READINGS: 
  1. Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones,  Jones and Barlett Publishers, Massachusetts, USA, 1998
  2. Human Genetics: Concepts and Applications, (2nd edition), R Lewis, WCB McGraw Hill, USA, 1997.
  3. Microbial Genetics, (2nd edition), Maloy, D Freidfelder and John E Cronan., Jones and Barlett Publishers, 1994
  4. Molecular genetics: An introductory narrative, (2nd edition), G S Stent and R Calendar, CBS Publishers and distributors, 2002
  5. Principles of Genetics, (8th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2005
  6. The Science of Genetics, Atherly, Girton, and McDonald ,Saunders College Publishing, Fort Worth, USA, 1999

 

REFERENCES: 

 

  1. Advanced Genetics, G S Miglani,  Narosa Publication House, 2003
  2. Cell Biology & Molecular Biology, (8th edition), E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2005
  3. Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000
  4. Genetics ,(3rd edition), M V Strickberger, Prentice Hall of India Pvt. Ltd., 2004                                                   
  5. Genetics, (5th edition), P J Russel, The Benjamin/Cummings Publishing Company,  USA.,1998
  6. Principles of Genetics, (2nd edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2000
Academic Year: 
2015-2016
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