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GENETICS AND MOLECULAR BIOLOGY
This course will enable students to develop in-depth understanding of Mendelian principles of genetics and extra nuclear inheritance, and evaluate variations in genetic material and genetic flow of information through replication, transcription and translation.
Mendelian Genetics-Mendel’s Experiment and Laws of inheritance, allelic and non-allelic interactions-co dominance, incomplete dominance, Epistasis (recessive and dominant), Complementary and Supplementary genes, duplicate and lethal genes. Sex determination mechanisms (XX-XY, ZZ-ZW and Haplodiploidy), Non-disjunction and Genetic balance theory, Dosage compensation, Sex linked inheritance.
Extra chromosomal inheritance, Maternal inheritance, uniparental inheritance and maternal effect.
Linkage, Recombination in bacteria-conjugation, transformation and transduction
Spontaneous and induced mutations, types of point mutations, physical and chemical mutagens. DNA repair mechanism- mismatch repair, base excision repair, Nucleotide excision repair, photoreactivation, Structural and numerical chromosomal aberrations. Hereditary defects in humans-Downs syndrome, Klinfelters syndrome and Turners syndrome.
DNA and Genome: The primary structure and packaging of DNA, Gene in molecular terms, physical and chemical nature of nucleic acid, types of DNA (A, B, Z). DNA replication in prokaryotes and eukaryotes, enzymes involved in replication, Recombination and repair (Holiday model).
Transcription in prokaryotes and eukaryotes, mRNA structure and synthesis.Ribozyme, Post-transcriptional modifications. Prokaryotic and eukaryotic translation, Post-translational modification of proteins and its breakdown.Regulation in prokaryotes and eukaryotes at genomic, transcription and translation level, Operon concept-positive and negative regulation of lac operon, trp operon.
- Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
- Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S. 9th edition, W. H. Freeman and Company, 2007.
- Genetics, (3rd edition), M V Strickberger, New Delhi : PHI Learning, 2012
- Molecular Cloning: a Laboratory Manual, J. Sambrook, E. F. Fritsch and I. Maniatis, Cold Spring harbor Laboratory Press, New York,2012.
- Genomes. Brown T.A: Published by Garland Science Publishing, a member of the Taylor & Francis Group, 2002
- Molecular Biology of the Cell (6th Edition) Bruce Albert, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter, 2014
- Molecular Biology of the Gene (7th Edition) Watson, Baker, Bell, Gann, Levin, Losick: Pearson Education.2017.
- Molecular Cell Biology (9th Edition) J. Darnell, H. Lodish and D.Baltimore, Macmillan learning, 2021.
- Freifelder’s Essentials of Molecular Biology. Malacinski, G M, Jones & Bartlett Publishers Inc. (2015)
Lewin’s Gene XII, Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick, 12th edition Jones and Bartlett Publishers, Inc, 2017
• Cell Biology & Molecular Biology, 8th edition, E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2017
• Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ: John Wiley & Sons, Inc., 2017
• From Genes to Clones by Winnacker, Panima Publishing Corporation, New Delhi/Bangalore, 2003
• Genetics – A molecular approach by Russell, Peter. J, 2016.
• Molecular Biology and biotechnology. A comprehensive desk reference. R. A. Meyers (Editor) VCH Publishers, Inc., New York, 1995.
