CELL BIOLOGY

Paper Code: 
BTE 121
Credits: 
5
Contact Hours: 
75
Objective: 

Course Outcomes (COs):

 

          Course Outcomes

Learning and teaching strategies

Assessment Strategies

Upon completion of the course the learner will:

CO1: Learn different attributes of cell structure & interactions

CO 2: Understand the role of cell division and its regulation on diseases like cancer.

CO3: Learn the cellular transport and mechanism of trafficking

CO4: Learn the cell signaling the signal transduction pathways

CO 5: Learn techniques in study of cytology

 

Class lectures

Seminars

Tutorials

Group discussions and Workshops

Question preparation

 

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects
 

 

 

15.00
Unit I: 
Ultrastructure of Cells and Cell- Cell interaction
  • Cell Structure and function
  • Structure and function of plasma membrane
  • Cytoskeleton: Self-assembly and dynamic structure of cytosketetal filaments, actin filament, microtubules, movement of cilia and flagella.
  • Cell –Cell interaction: cell adhesion, tight and gap junctions, plasmodesmata.

 

18.00
Unit II: 
Cell cycle and Cancer Prognosis
  • Cell cycle and apoptosis: Events in cell cycle, mitosis and meiosis, Key regulators of cell cycle, programmed cell death and its control.
  • Cancer and the cell cycle, Oncogenes, tumor suppressor genes, virus-induced cancer, metastasis, interaction of cancer cells with normal cells, apoptosis, therapeutic interventions of uncontrolled cell growth.

 

15.00
Unit III: 
Transport across membranes
  • Membrane transport: Thermodynamics of transportation, passive and active mediated transportation of molecules, Donnan equilibrium, Nernst equation, Na+- K+ ATPase, H+-K+ ATPase, ion gradient driven transportation, mechanism of protein trafficking

 

 

17.00
Unit IV: 
Signal transduction
  • Molecular basics of signal transduction in bacteria, plants and animals, secondary messengers, perception of environmental signals, G- protein and tyrosine kinase coupled receptors.

 

10.00
Unit V: 
Techniques in Cell Biology
  • Basic techniques in cell biology: microscopy, cell fractionation method, GISH, FISH, histochemical analysis, microtomy, staining and fixation, Confocal Microscopy

 

ESSENTIAL READINGS: 

ESSENTIAL READINGS:

  • Molecular Biology of the Cell (6th Edition). Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts. Publishers W.W. Norton. 2014
  • Cell Biology (3rd Edition). Pollard. Publishers ‎ ELSEVIER IE (SHORT DISC) 2017
  • Becker's World of the Cell, Global Edition (9th Edition). Jeff Hardin, Gregory Bertoni, Lewis Kleinsmith. Publishers Pearson. 2017

 

RECOMMENDED READINGS:

  • Molecular Biology of the Cell (4th Edition) B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J.D. Watson, Garland publishing. Inc., New York, 2002.
  • Molecular Cell biology (9th Edition) Harvey Lodish, Arnold Berk, Chris A. Kaiser (Author), Monty Krieger, Anthony Bretscher, W H Freeman & Co; (27 January 2021)
  • Cell & Molecular Biology, (8th edition), E D P Roberties& E M F Roberties, Lippincott Williams & Wilkins, 2005
  • Cell and Molecular Biology, (3rd edition), P Scheeler and D E Bianchi, John Wiley & Sons, Inc, 1987
  • Cell and Molecular Biology: Concepts and Experiments, (7th edition), G Karp, John Wiley & sons, Inc., 2013
  • The cell. A Molecular Approach, (8th edition), G H Cooper and R E Hausman, ASM Press, 2020

 

REFERENCES: 

e RESOURCES:

•   Cell-Cell Interactions - The Cell - NCBI Bookshelf (nih.gov)

•   Cell Biology - Organelles, Cycles and Division, Signaling & Techniques (microscopemaster.com)

•   From the Academy: The cell cycle and cancer - PMC (nih.gov)

•   Pathways and Diagrams | Cell Signaling Technology

 

JOURNALS:

•   Journal of Cell Biology

•   Advances in Cell & Gene Therapy

•   Journal of Cancer Epidemiology

 

 

 

Academic Year: 
2022-2023
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