Genetics

Paper Code: 
BTE 301
Credits: 
03
Contact Hours: 
45
Objective: 

This paper will enable students to-

  • learn the basics of Genetics and its importance in biological systems
  • study sex linked inheritance in plant and animals
  • learn the basics of linkage and bacterial recombination
  • learn the basics of mutation and its effect on evolution and health
  • study the fundamentals of population genetics
9.00
Unit I: 
Mendelian genetics

Mendelian genetics-Mendel’s Experiment and Laws of inheritance, Gene interactions-co dominance and incomplete dominance Epistasis (recessive and dominant), Complementary and Supplementary genes, Lethal genes.

9.00
Unit II: 
Sex determination & sex linked inheritance

Sex determination mechanisms in plants and animals. Non-disjunction theory and Genetic balance theory, Sex chromatin bodies and Dosage compensation, Sex linked inheritance.

9.00
Unit III: 
Linkage, Recombination & Genetic system

Linkage and mapping genes, CIS-TRANS or complementation test for functional allelism.

Recombination in bacteria-conjugation, transformation and transduction.

10.00
Unit IV: 
Mutations

Spontaneous and induced mutations, types of point mutations, physical and chemical mutagens. Structural and numerical chromosomal aberrations.

Replica plating technique to isolate mutants.

Evolution of wheat, cotton and Raphanobrassica.  Hereditary defects in humans-Downs syndrome, Klinfelters syndrome and Turners syndrome.

8.00
Unit V: 
Extra chromosomal inheritance & population genetics

Extra chromosomal inheritance, maternal effect, chloroplast and mitochondrial genetic system.

Population genetics-gene and genotype frequency, Hardy-Weinberg equilibrium.

ESSENTIAL READINGS: 
  1. Gene IX, Lewin, Oxford university Press, 2007
  2. Microbial Genetics, 2nd edition, Maloy, D Freidfelder and John E  Cronan., Jones and Barlett Publishers, 1994
  3. Principles of Genetics, 8th edition, E J Gardener, M J Simmons and D P Snustad, John Wiley and Sons Publications, 2005
REFERENCES: 
  1. Advanced Genetics, G S Miglani,  Narosa Publication House, 2003
  2. Cell Biology & Molecular Biology, 8th edition, E D P Roberties and E M F Roberties, Lippincott Williams and Wilkins, 2005
  3. Fundamental Genetics, J Ringo, Cambridge University Press, 2004
  4. Genetics, 3rd edition, M V Strickberger, Prentice Hall of India Pvt. Ltd., 2004                                                   
Academic Year: