IMMUNOLOGY

Paper Code: 
MBL 223
Credits: 
05
Contact Hours: 
75
Objective: 

This course will enable the students to –

 

  1. understand the various cells involved in Immune system.
  2. learn the cellular and molecular aspects of Immune system.
  3. study about the regulation of Immune response and Antigen – Antibody reactions.
  4. learn about the applied aspects of Immunology.

Course Outcomes (COs): 

Course

Learning outcome (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

MBL 223

 

Immunology

 

Upon completion of the course students will be able to

CO 40: Evaluate fundamental bases of immune system and immune response

CO 41: Assess the mechanisms which underlie the immune response

CO 42: Acquaint with different antigen-antibody interaction techniques

CO 43:  Acquaint with applications of Immunology

  Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self learning assignments, Effective questions, Giving tasks

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation

 

 
15.00
Unit I: 
Introduction to immune system

Basic Immunology: - Phylogeny of immune system, Innate and acquired immunity, Clonal nature of immune response. Cells of the Immune system: Hematopoiesis and differentiation, Lymphocyte trafficking, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK and Lymphokine activated killer cells, Eosinophils, Neutrophils and Mast Cells. Organization and structure of lymphoid organs.

15.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens. Immunoglobulin: structure, types and their function, Major histocompatibility complex, B-Cell Receptor and T-Cell Receptor, generation and diversity, Complement system

18.00
Unit III: 
Immune response & its regulation

Antigen processing and presentation, generation of Humoral and Cell mediated immune responses, B- and T- cell maturation, activation and differentiation, Cytokines and their role in immune regulation, T-cell regulation, MHC restriction, Immunological tolerance, Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity       

12.00
Unit IV: 
Antigen- antibody interactions

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence        

15.00
Unit V: 
Advanced concepts in Immunology

Hypersensivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity of infectious agents (intracellular parasites, helminthes and viruses), Tumor Immunology, AIDS and other immunodeficiencies, Hybridoma Technology and Monoclonal antibodies.

ESSENTIAL READINGS: 
  1. Kuby’s Immunology, (4th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York.
  2. Roitt’s Essential Immunology,(10th edition), Ivan M .Roitt and Peter J. Delves, Blackwell Science, 2001
  3. Instant Notes on Immunology, (2nd edition),  Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003
REFERENCES: 
  1. Cellular and Molecular Immunology, (3rd edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
  2. Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  3. Medical Microbiology and Immunology: Examination and Board Review, (7th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002
Academic Year: 
2020-2021
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