Immunology

Paper Code: 
MBL 401
Credits: 
03
Contact Hours: 
45
Objective: 

This paper will enable students to understand –

 

  1. The nature of biological material and hierarchy of molecular organization of cells.
  2. The thermodynamic principles underlying biochemical reactions and the function of macromolecules.
  3. The students will learn the concept of enzyme catalysis, reaction mechanism and regulation of enzyme activity

 

Course Outcomes (COs):

 

Course

Learning outcome (at course level)

Learning and teaching

strategies

Assessme nt Strategies

Paper Code

Paper Title

 

 

CO 48

Approach          in

C   A    test,

 

 

Learn the fundamentals of

teaching:

Semester

 

 

immune system

Interactive

end

 

 

CO 49

Lectures,

examinatio

 

 

Study the various cellular

Discussion,

ns,      Quiz,

 

 

and molecular   aspects   of

Tutorials,

Solving

 

 

immune system

Reading

problems in

 

 

CO 50

assignments,

tutorials,

 

 

Understand the regulation of

presentations

Assignment

MBL 401

Immunol ogy

immune response

CO 51

Understand     the     role     of

 

Learning activities for the

s,

Classroom interaction

 

 

different     types    of    Cells,

students:

 

 

 

Effector       Molecules      and

Self-learning

 

 

 

Effector      Mechanisms      in

assignments,

 

 

 

Immunology.

Effective

 

 

 

CO 52

questions,

 

 

 

Understand    the    principles

Seminar

 

 

 

underlying                  various

presentation,

 

 

 

Immunotechniques.

Giving tasks.

 

 

8.00
Unit I: 
Basic Immunology
  • Introduction to immune system- Innate and acquired immunity
  • Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells. Structure and function of lymphoid organs

 

11.00
Unit II: 
Cellular and molecular aspects
  • Nature and biology of antigens and super antigens
  • Immunoglobulin: structure, types and their function
  • MHC, B and T-Cell Receptor
  • Complement system

 

10.00
Unit III: 
Immune response & its regulation

·         Generation of Humoral and Cell mediated immune responses

·         B-and T- cell maturation, activation and differentiation

·         Cytokines and their role in immune regulation

·         T-cell regulation, MHC restriction

Immunological tolerance

7.00
Unit IV: 
Antigen- antibody interactions
  • Antigen processing and presentation
  • Precipitation,      Immunodiffusion,      Immunoelectrophoresis,      Agglutination,       RIA,     ELISA, Immunofluorescence

 

9.00
Unit V: 
Selected concepts in Immunology
  • Hypersenstivity
  • Autoimmunity
  • Vaccine Types: RD vaccines, Peptides, Proteins, DNA
  • AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)

 

ESSENTIAL READINGS: 
  • Kuby Immunology, 4th edition- R.A. Goldsby and others, Freeman & Co., New York, 2001
  • Roitt’s, Essential Immunology, 10th edition, Ivan M Roitt and Peter J Delves, Blackwell Science, 2001
  • Instant Notes on Immunology, 2nd edition, Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003
  • Cellular and Molecular Immunology, 3rd edition, Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
  • Immunology: A Comprehensive Review, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  • Medical Microbiology and Immunology: Examination and Board Review, 7th edition, Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002

 

Academic Year: 
2021-2022
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