IMMUNOLOGY

Paper Code: 
MBL 401
Credits: 
03
Contact Hours: 
45
Objective: 

Course Outcomes (COs):

Course Outcomes

Learning and teaching strategies

Assessment Strategies

Upon completion of the course the learner will:

CO 46: understand the role of different cells and organs in immunology.

CO 47: classify and compare the molecules of immunity (antibodies, MHC, B- and T-cell receptors, cytokines).

CO 48: explain the mechanism of generation of immune response and its regulation.

CO 49: interpret and compare the type of immune response generated against different diseases.

CO 50: understand the antigen-antibody interactions and utilize them for detecting immunological disorders.

Interactive Lectures, Discussion, Tutorials, Demonstrations, Assignments

 

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects
 

 

8.00
Unit I: 
Basic Immunology
  • Introduction to immune system- Innate and acquired immunity
  • Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells. Structure and function of lymphoid organs.

 

 

11.00
Unit II: 
Cellular and molecular aspects
  • Nature and biology of antigens and super antigens
  • Immunoglobulin: structure, types and their function
  • MHC, B and T-Cell Receptor
  • Complement system

 

10.00
Unit III: 
Immune response & its regulation
  • Generation of Humoral and Cell mediated immune responses
  • B-and T- cell maturation, activation and differentiation
  • Cytokines and their role in immune regulation
  • T-cell regulation, MHC restriction
  • Immunological tolerance

 

7.00
Unit IV: 
Antigen- antibody interactions
  • Antigen processing and presentation
  • Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

 

9.00
Unit V: 
Selected concepts in Immunology
  • Hypersenstivity
  • Autoimmunity
  • Vaccine Types: RD vaccines, Peptides, Proteins, DNA
  • AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)

 

ESSENTIAL READINGS: 
  • Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York, 2018.
  • Roitt’s Essential Immunology,(13th edition), Ivan M.Roitt and Peter J. Delves, Blackwell Science, 2017
  • Instant Notes on Immunology, (3rdedition),Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011

 

REFERENCES: 

SUGGESTED READINGS:

  • Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017
  • Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002
  • Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004

e RESOURCES:

·National Health Mission Immunization: National Health Mission (nhm.gov.in)

JOURNALS:

 

Academic Year: 
2022-2023
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