IMMUNOLOGY

Paper Code: 
BTE 401
Credits: 
3
Contact Hours: 
45
Objective: 

Upon completion of the course the learner will:

CO 46:  Understand the role of different cells and organs in immunology.

CO 47: Classify and compare the molecules of immunity (antibodies, MHC, B- and T-cell receptors, cytokines).

CO 48: Explain the mechanism of generation of immune response and its regulation.

CO 49: Interpret and compare the type of immune response generated against different diseases.

CO 50: Understand the antigen-antibody interactions and utilize them for detecting immunological disorders.

8.00
Unit I: 
Basic Immunology
  • Introduction to immune system- Innate and acquired immunity
  • Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells. Structure and function of lymphoid organs.

 

 

11.00
Unit II: 
Cellular and molecular aspects
  • Nature and biology of antigens and super antigens
  • Immunoglobulin: structure, types and their function
  • MHC, B and T-Cell Receptor
  • Complement system

 

 

10.00
Unit III: 
Immune response& its regulation
  • Generation of Humoral and Cell mediated immune responses
  • B-and T- cell maturation, activation and differentiation
  • Cytokines and their role in immune regulation
  • T-cell regulation, MHC restriction
  • Immunological tolerance

 

 

7.00
Unit IV: 
Antigen- antibody interactions
  • Antigen processing and presentation
  • Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

 

 

9.00
Unit V: 
Selected concepts in Immunology
  • Hypersenstivity
  • Autoimmunity
  • Vaccine Types: RD vaccines, Peptides, Proteins, DNA
  • AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)

 

ESSENTIAL READINGS: 
  • Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York, 2018.
  • Roitt’s Essential Immunology, (13th edition), Ivan M. Roitt and Peter J. Delves, Blackwell Science, 2017
  • Instant Notes on Immunology, (3rd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011

 

 

REFERENCES: 

SUGGESTED READINGS:

  • Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017
  • Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002
  • Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004

 

e RESOURCES:

·National Health Mission Immunization :: National Health Mission (nhm.gov.in)

 

JOURNALS:

 

 

Academic Year: 
2022-2023
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