Immunology

Paper Code: 
BTE 401
Credits: 
3
Contact Hours: 
45
Objective: 

This paper will enable students to-

  • learn the fundamentals of immune system
  • study the various cellular and molecular aspects of immune system
  • understand the regulation of immune response
  • learn various immunological diagnostic techniques
8.00
Unit I: 
Basic Immunology

Introduction to immune system- Innate and acquired immunity

Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells. Structure and function of lymphoid organs

11.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens

Immunoglobulin: structure, types and their function

MHC, B and T-Cell Receptor

Complement system

10.00
Unit III: 
Immune response & its regulation

Generation of Humoral and Cell mediated immune responses

B-and T- cell maturation, activation and differentiation

Cytokines and their role in immune regulation

T-cell regulation, MHC restriction

Immunological tolerance

7.00
Unit IV: 
Antigen- antibody interactions

Antigen processing and presentation

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

9.00
Unit V: 
Selected concepts in Immunology

Hypersenstivity

Autoimmunity

Vaccine Types: RD vaccines, Peptides, Proteins, DNA

AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome

ESSENTIAL READINGS: 
  1. Kuby Immunology, R.A. Goldsby and others, 4th edition, Freeman & Co., New York, 2001
  2. Roitt’s Essential Immunology, Ivan M .Roitt and Peter J. Delves, 10th edition, Blackwell Science, 2001
  3. Instant Notes on Immunology, Lydyard, Wheran and Fanger, 2nd edition, Viva Books Pvt. Ltd., 2003
REFERENCES: 
  1. Cellular and Molecular Immunology, Abbas, Litchman and Pober, 3rd edition, Harcourt Brace and Company, 1998
  2. Immunology: A Comprehensive, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  3. Medical Microbiology and Immunology: Examination and Board Review by Warren Levinson and Ernst Jawetz, 7th edition, Mc Graw Hill, 2002


 

Academic Year: 
2019-2020
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