IMMUNOLOGY

Paper Code: 
24CBTE401
Credits: 
04
Contact Hours: 
60
Objective: 

This course will enable the students to learn about structural and functional features of components of immune system. The major emphasis of this course will be on development of immune system and mechanisms by which our body elicits immune response. This will be imperative for students as it will help them to predict about nature of immune response that develops against bacterial, viral or parasitic infection, and prove it by designing new experiments.

12.00
Unit I: 
Introduction to immune system

History of Immunology, Innate and acquired immunity, Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells. Organization, structure, and function of lymphoid organs

12.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens, Immunoglobulin: structure, types and their function

HLA typing and major histocompatibility complex, T-Cell Receptors: Generation and diversity, Complement system           

12.00
Unit III: 
Immune response & its regulation

Antigen processing and presentation, Generation of Humoral and Cell mediated immune responses: B- and T- cell maturation (MHC restriction, Immunological tolerance), activation and differentiation, T-cell regulation, Cytokines and their role in immune regulation, Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity

 

12.00
Unit IV: 
Antigen- antibody interactions

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, Immunofluorescence microscopy and flow cytometry, ELISA, ELISPOT Assay, lymphoproliferation assay, mixed lymphocyte reaction                                                                            

12.00
Unit V: 
Advanced concepts in Immunology

Hypersensitivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity against infectious agents (intracellular parasites, helminthes and viruses), Tumor immunology, AIDS and other immune-deficiencies, Monoclonal antibodies: Hybridoma Technology, Phage display, Humanized antibodies

 

ESSENTIAL READINGS: 
  • Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A.    

      Osbarne, (Freeman) & Co. New York, 2018.

  • Roitt’s Essential Immunology, (13th edition), Ivan M. Roitt and Peter J. Delves,    

      Blackwell Science, 2017

  • Instant Notes on Immunology, (3rd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011

 

 

REFERENCES: 
  • Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017
  • Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002
  • Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004

 

Academic Year: 
2024-2025
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