IMMUNOLOGY

Paper Code: 
BTE 223
Credits: 
05
Contact Hours: 
75
Objective: 

to enable students to-

  • understand the various cells involved in Immune system.
  • learn the cellular and molecular aspects of Immune system.
  • study about the regulation of Immune response and Antigen – Antibody reactions.
  • learn about the applied aspects of Immunology.
20.00
Unit I: 
Introduction to immune system

Basic Immunology: - Phylogeny of immune system, Innate and acquired immunity, Clonal nature of immune response. Cells of the Immune system: Hematopoiesis and differentiation, Lymphocyte trafficking, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK and Lymphokine activated killer cells, Eosinophils, Neutrophils and Mast Cells. Organization and structure of lymphoid organs       

15.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens. Immunoglobulin: structure, types and their function, Major histocompatibility complex, B-Cell Receptor and T-Cell Receptor, generation and diversity, Complement system

20.00
Unit III: 
Immune response & its regulation

Antigen processing and presentation, generation of Humoral and Cell mediated immune responses, B- and T- cell maturation, activation and differentiation, Cytokines and their role in immune regulation, T-cell regulation, MHC restriction, Immunological tolerance, Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity

10.00
Unit IV: 
Antigen- antibody interactions

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence        

10.00
Unit V: 
Advanced concepts in Immunology

Hypersensitivity, Autoimmunity, Vaccine development and immunization programme, Transplantation & immunization programe , Immunity of infectious agents (intracellular parasites, helminthes and viruses), Tumor Immunology, AIDS and other immunodeficiencies, Hybridoma Technology and Monoclonal antibodies.

ESSENTIAL READINGS: 
  1. Kuby’s Immunology, (4th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York.
  2. Roitt’s Essential Immunology,(10th edition), Ivan M .Roitt and Peter J. Delves, Blackwell Science, 2001
  3. Instant Notes on Immunology, (2nd edition),  Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003
REFERENCES: 
  1. Cellular and Molecular Immunology, (3rd edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
  2. Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  3. Medical Microbiology and Immunology: Examination and Board Review, (7th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002
Academic Year: 
2014-2015
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