MEDICAL MICROBIOLOGY

Paper Code: 
MBL 402
Credits: 
03
Contact Hours: 
45
Objective: 

to enable students:

  • To learn about normal microbial flora of body and establishment of pathogenesis
  • To know about different types of diseases caused by bacteria
  • To know about viral diseases of humans
  • To learn about chemotherapeutic agents
10.00
Unit I: 
Beneficial and Harmful Microbial Interactions with Human

Normal microbial population of healthy human body - Skin, mouth, upper respiratory tract, intestinal tract, urino-genital tract.

Mechanism of bacterial pathogenicity, Entry of pathogens into the host, colonization and growth, Virulence, Virulence factors – exotoxins, enterotoxins, endotoxins.

8.00
Unit II: 
Epidemiology: the study of disease in population

Principles of epidemiology, reservoirs of pathogens, acquisition and transmission of infectious agents, Nosocomical infections, Measures for prevention of epidemics. Immunization program in India.

9.00
Unit III: 
Bacterial diseases

General idea of infections: symptoms, treatment and preventive measure of diseases caused by Gram positive bacteria: Mycobacterium (Tuberculosis and leprosy), Corynebacterium(Diphtheria) and Gram negative bacteria: Salmonella (Typhoid), Vibrio (cholera), Shigella (Dysentry), Niseeria (Gonorrhea).

9.00
Unit IV: 
Viral diseases

Animal viruses life cycle, pathogenicity, diagnosis, prevention and treatment of RNA viruses- Picorna virus- Poliomyelitis; Orthomyxoviruses-influenza viruses.

Paramyxoviruses- Mumps, Measles; retroviruses- HIV, Rabies virus.

DNA viruses- Herpes virus- Varicella zoster virus;Hepatitis viruses-HBV.

Unit V: 
Antibiotics and synthetic antimicrobial agents

Characters of an ideal chemotherapeutic agent, Classification of Antibiotics based on their structure, Mechanism of action of antibiotics (inhibitors of cell wall synthesis, nucleic acid and protein synthesis, metabolic antagonists).

Development of antibiotic resistance in bacteria.

ESSENTIAL READINGS: 
  1. Instant Notes Medical Microbiology, Irving W, Boswell T, Ala Aldeen D, Taylor and Francis group, 2005
  2. Medical virology- Morag C and Timbury M.C. X Edition. Churchill Livingstone, London. 1994
  3. Microbiology A Human Perspective, Nester E.W., Roberts CE, Nester MT, Wm. C. Brown Publishers, 1995.
  4. Text book of Microbiology, R Ananthnarayanan and C K J Paniker, Orient Longman, 1997
REFERENCES: 
  1. Bailey and Scott’s Diagnostic Microbiology, Baron EJ, Peterson LR and Finegold SM, Mosby, 1990
  2. Medical Microbiology and Immunology: Examination and Board Review (7th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002.
  3. Review of Medical Microbiology (13th edition), Jawetz E., Melnik J.L., Adelberg E. A., Lanze Medical Publications, 1976.
Academic Year: 
2019-2020
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