MEDICAL MICROBIOLOGY

Paper Code: 
MBL 402
Credits: 
03
Contact Hours: 
45
Objective: 

Course Outcomes (COs):

Course Outcomes

Learning and teaching strategies

Assessment Strategies

Upon completion of the course learners will be able to:

CO 51:  analyze the different aspects of host-microbe interactions and identify the role of resident flora in maintaining health.

CO 52: analyze the factors responsible for emergence and prevention of epidemics.

CO 53:   Evaluate the pathogenesis of bacterial diseases and identify the laboratory-based methods for their identification.

CO 54:   Understand the life cycle of pathogenic viruses, identify the methods for their diagnosis treatment and prophylaxis.

CO 55:   Differentiate, compare and contrast the mode of action of antibiotics and evaluate their resistance mechanisms.

Interactive Lectures,

Discussion,

Tutorials,

Demonstrations,

Assignments

Reading JOURNALS:

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects
 

 

10.00
Unit I: 
Beneficial and Harmful Microbial Interactions with Human
  • Normal microbial population of healthy human body - Skin, mouth, upper respiratory tract, intestinal tract, urino-genital tract.
  • Mechanism of bacterial pathogenicity, Entry of pathogens into the host, colonization and growth, Virulence, Virulence factors – exotoxins, enterotoxins, endotoxins.

 

8.00
Unit II: 
Epidemiology: the study of disease in population

Principles of epidemiology, reservoirs of pathogens, acquisition and transmission of infectious agents, Nosocomical infections, emerging and reemerging diseases, Measures for prevention of epidemics. Immunization program in India.

9.00
Unit III: 
Bacterial diseases
  • General idea of infections: symptoms, treatment and preventive measure of diseases caused by Gram positive bacteria: Mycobacterium (Tuberculosis and leprosy), Corynebacterium(Diphtheria) and Gram negative bacteria: Salmonella (Typhoid), Vibrio (cholera), Shigella (Dysentry), Niseeria (Gonorrhea).

 

9.00
Unit IV: 
Viral diseases
  • Animal viruseslife cycle, pathogenicity, diagnosis, prevention and treatment of RNA viruses- Picorna virus- Poliomyelitis; Orthomyxoviruses-influenza viruses.
  • Paramyxoviruses- Mumps, Measles; retroviruses- HIV, Rabies virus.
  • DNA viruses- Herpes virus- Varicella zoster virus;Hepatitis viruses-HBV.

 

Unit V: 
Antibiotics and synthetic antimicrobial agents
  • Characters of an ideal chemotherapeutic agent, Classification of Antibiotics based on their structure, Mechanism of action of antibiotics (inhibitors of cell wall synthesis, nucleic acid and protein synthesis, metabolic antagonists).
  • Development of antibiotic resistance in bacteria.

 

ESSENTIAL READINGS: 
  • Jawetz, Melnick & Adelberg’s Medical Microbiology, Geo. Brooks, Karen C. Carroll, Janet Butel, Stephen Morse, 24th Edition. McGraw-Hill Medical, 2007
  • Brock biology of microorganisms. Madigan, M. T., Bender, K. S., Buckley, D. H., Sattley, W. M., & Stahl, D. A.16th ed Hoboken, NJ : Pearson Education, 2021
  • Instant Notes Medical Microbiology, Irving W, Boswell T, Ala Aldeen D, Taylor and Francis group, 2005
  • Text book of Microbiology, R Ananthnarayanan and C K J Paniker, 10th ed. Orient Longman Private Ltd, India, 2017

 

REFERENCES: 

SUGGESTED READINGS:

  • Microbiology A Human Perspective, Nester E.W., Roberts CE, Nester MT, Wm. C. McGraw-Hill Medical Publishing, 2009
  • Bacterial Pathogenesis: A Molecular Approach.  Wilson, Brenda A.; Salyers, Abigail A.; Whitt, Dixie D; Winkler, Malcolm E. 3 ed. Washington, DC : ASM Press, 2011.
  • Mackie and McCartney practical medical microbiology. Mackie, T. J., Collee, J. G., & McCartney, J. E. 14th ed., New Delhi (India): Elsevier 2007
  • Fenner and White's Medical Virology Christopher J. Burrell, Colin R. Howard, Frederick A. Murphy, 5th edition, Academic Press; 5th edition, 2016

 

e RESOURCES:

JOURNALS:

  • Indian Journal of Medical Microbiology
  • Frontiers in Microbiology

 

 

Academic Year: 
2022-2023
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