MEDICAL MICROBIOLOGY

Paper Code: 
MBL 402
Credits: 
03
Contact Hours: 
45
Objective: 

This paper will enable students to understand –

 

  1. The nature of biological material and hierarchy of molecular organization of cells.
  2. The thermodynamic principles underlying biochemical reactions and the function of macromolecules.
  3. The students will learn the concept of enzyme catalysis, reaction mechanism and regulation of enzyme activity

Course Outcomes (COs):

Course

Learning outcome (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

MBL 402

Medical Microbiology

CO 1 Understand different types of diseases caused by bacteria

CO 2 Understand the basics of pharmaceutical microbiology and important microorganism playing role pharmaceutically

CO 3 Understand role of secondary metabolites in pharmaceutical industry.

CO 4 Well versed with the different microbial products used in pharmaceutical applications

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, presentations

 

Learning activities for the students:

Self-learning assignments, Effective questions, Seminar presentation, Giving tasks.

 

C A test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Classroom interaction

 

10.00
Unit I: 
Beneficial and Harmful Microbial Interactions with Human

          

Normal microbial population of healthy human body - Skin, mouth, upper respiratory tract, intestinal tract, urino-genital tract.

Mechanism of bacterial pathogenicity, Entry of pathogens into the host, colonization and growth, Virulence, Virulence factors – exotoxins, enterotoxins, endotoxins.

 

8.00
Unit II: 
Epidemiology: the study of disease in population

                  

Principles of epidemiology, reservoirs of pathogens, acquisition and transmission of infectious agents, Nosocomical infections, Measures for prevention of epidemics. Immunization program in India.

 

9.00
Unit III: 
Bacterial diseases

 

General idea of infections: symptoms, treatment and preventive measure of diseases caused by Gram positive bacteria: Mycobacterium (Tuberculosis and leprosy), Corynebacterium(Diphtheria) and Gram negative bacteria: Salmonella (Typhoid), Vibrio (cholera), Shigella (Dysentry), Niseeria (Gonorrhea).

 

 

9.00
Unit IV: 
Viral diseases

                                                 

Animal viruses life cycle, pathogenicity, diagnosis, prevention and treatment of RNA viruses- Picorna virus- Poliomyelitis; Orthomyxoviruses-influenza viruses.

Paramyxoviruses- Mumps, Measles; retroviruses- HIV, Rabies virus.

DNA viruses- Herpes virus- Varicella zoster virus;Hepatitis viruses-HBV.

 

9.00
Unit V: 
Antibiotics and synthetic antimicrobial agents

                        

Characters of an ideal chemotherapeutic agent, Classification of Antibiotics based on their structure, Mechanism of action of antibiotics (inhibitors of cell wall synthesis, nucleic acid and protein synthesis, metabolic antagonists).

Development of antibiotic resistance in bacteria.

 

ESSENTIAL READINGS: 
  1. Instant Notes Medical Microbiology, Irving W, Boswell T, Ala Aldeen D, Taylor and Francis group, 2005
  2. Medical virology- Morag C and Timbury M.C. X Edition. Churchill Livingstone, London. 1994
  3. Microbiology A Human Perspective, Nester E.W., Roberts CE, Nester MT, Wm. C. Brown Publishers, 1995.
  4. Text book of Microbiology, R Ananthnarayanan and C K J Paniker, Orient Longman, 1997

 

REFERENCES: 
  1. Bailey and Scott’s Diagnostic Microbiology, Baron EJ, Peterson LR and Finegold SM, Mosby, 1990
  2. Medical Microbiology and Immunology: Examination and Board Review (7th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002.
  3. Review of Medical Microbiology (13th edition), Jawetz E., Melnik J.L., Adelberg E. A., Lanze Medical Publications, 1976.

 

 

Academic Year: 
2020-2021
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