This course will enable the students to -
Course Outcomes (COs):
Course |
Learning outcome (at course level) |
Learning and teaching strategies |
Assessment Strategies |
|
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Paper Code |
Paper Title |
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BTE 123
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Microbiology |
Upon completion of the course students will be able to: CO 8: Understand microbial evolution and bacterial taxonomy. CO 9:Understand structural components of bacterial cell and microbial growth CO 10: Assess diversity of bacteria CO 11: Understand host parasite relationship, epidemiology and chemotherapy |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments Learning activities for the students: Self-learning assignments, Effective questions, Presentation, Giving tasks |
Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation. |
Microbial evolution, systematic and taxonomy-Evolution of earth and earliest life forms; primitive organisms, their metabolic strategies and molecular coding; approaches to bacterial taxonomy, DNA-DNA and DNA-RNA hybridization, G+C content determination, ribotyping, Ribosomal RNA sequencing; Characteristics of primary domains, Taxonomy, Nomenclature and Bergey's Manual. Culture collection, maintenance and preservation of microorganisms.
Cell wall composition and synthesis. Flagella, Cilia and motility. Cell inclusions like Glycogen granules, Volutin granules, Carboxysomes etc, Endospores, Slime sheet and capsule.
Microbial Growth-The definition of growth, mathematical expression of growth, growth curve, measurement of growth and growth yields, Synchronous growth, Continuous, Batch and Fed Batch Culture; Growth as affected by environmental factors like temperature, acidity, alkalinity, water availability and oxygen; nutritional classification of microorganisms
Structure of archebacteria and eukaryotic cells.
Archaea: Archaea as earliest life forms; Halophiles, Methanogens; Hyperthermophilic archaea and Thermo plasma,
Eukarya: Algae, Fungi, Slime molds and Protozoa.
Chemolithotrophy; Hydrogen, Iron, Nitrate and oxidizing bacteria; Nitrate and sulfate reduction; Syntrophy; Role of anoxic decomposition; Nitrogen fixation
Normal micro flora of skin, oral cavity, gastrointestinal tract. Anaerobic ecosystem- Rumen microbiology.
Entry of pathogens into the host; colonization and factors predisposing to infections; types of toxins (Exotoxin, Endotoxin and Enterotoxin) and their structure; mode of actions; virulence and pathogenesis
Disease reservoirs; Epidemiological terminologies; infectious disease transmission;
Emerging and resurgent infectious diseases (Tuberculosis chicken pox, AIDS, hepatitis
Malaria)
Chemotherapy and Antimicrobial agents; Sulfa drugs; Antibiotics; Pencillins and Cephalosporins; Broad-Spectrum antibiotics; Antibiotics from prokaryotes; Antifungal antibiotics; Mode of action; Resistance to antibiotics.