GENETICS

Paper Code: 
MBL 125
Credits: 
2
Contact Hours: 
30
Objective: 

Course Outcomes (COs):

             

            Course Outcomes

Learning and teaching strategies

Assessment Strategies

  
 

Upon completion of the course the learner will:

CO 25: Understand the fundamental molecular principles of genetics in prokaryotes and eukaryotes

CO 26: Differentiate, compare and contrast different types of gene interactions and predict the outcomes of these interactions.

CO 27: Apply the knowledge of genetic crosses to construct genetic maps.

CO 28: Evaluate the processes that cause changes in the kind and amount of genetic variation in populations.

CO 29: Understand extrachromosomal inheritance and Hardy Weinberg equilibrium.

CO 30: Analyse the relationship between phenotype and genotype in human  genetic traits

Interactive Lectures,

Discussion,

Tutorials, Demonstrations,

Assignments

Reading Journals

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects

  

 

10.00
Unit I: 
Genetics of bacteria and bacteriophages

Concept of a gene in pre-DNA era; mapping of genes in bacterial and phage chromosomes by classical genetic crosses; fine structure analysis of a gene; genetic complementation and other genetic crosses using phenotypic markers; phenotype to genotype connectivity prior to DNA-based understanding of gene.

 

8.00
Unit II: 
Yeast genetics

Meiotic crosses, tetrad analyses, non-Mendelian and Mendelian ratios, gene conversion, models of genetic recombination, yeast mating type switch; dominant and recessive genes/mutations, suppressor or modifier screens, complementation groups, transposon mutagenesis, synthetic lethality, genetic epistasis.

 

4.00
Unit III: 
Drosophila genetics as a model of higher eukaryotes

Monohybrid & dihybrid crosses, back-crosses, test-crosses, analyses of autosomal and sex linkages, screening of mutations based on phenotypes and mapping the same, hypomorphy, genetic mosaics, genetic epistasis in context of developmental mechanism

4.00
Unit IV: 
Population genetics and genetics of evolution

Introduction to the elements of population genetics: genetic variation, genetic drift, neutral evolution; mutation selection, balancing selection, Fishers theorem, Hardy- Weinberg equilibrium, linkage disequilibrium; in-breeding depression & mating systems; population bottlenecks, migrations, Bayesian statistics; adaptive landscape, spatial variation & genetic fitness.

 

4.00
Unit V: 
Quantitative genetics of complex traits (QTLs) and Plant genetics

Complex traits, mapping QTLs, yeast genomics to understand biology of QTLs.

Laws of segregation in plant crosses, inbreeding, selfing, heterosis, maintenance of genetic purity, gene pyramiding.

 

ESSENTIAL READINGS: 
  • Genetics, conceptual approach, Benjamin A Pierce, 7th edition, W. H. Freeman and Company, 2019
  • Introduction to genetic analysis, Griffiths, A., Wessler, S., Lewontin, R., Carroll, S.  9th edition, W. H. Freeman and Company, 2007.
  • Principles of genetics, D Peter Snustad; Michael J Simmons, 7th edition, Hoboken, NJ: John Wiley & Sons, Inc., 2017
  • Microbial Genetics, Stanly R Maloy, John E Cronan Jr. and David Freifelder. 2nd edition, Narosa publishing house, New Delhi. 2006.
  • iGenetics- A Molecular Approach, Russell PJ., 3rd edition, Benjamin Cummings. 2009.
  • Principles of Genetics Tamarin, R. H., & Leavitt, R. W. Dubuque, IA: Wm. C. Brown (1991).
  • Evolutionary Genetics. Smith, J. M. Oxford: Oxford University Press, 1998

 

REFERENCES: 

SUGGESTED READINGS:

  • Molecular Genetics of Bacteria, Larry Snyder, Joseph E. Peters, Tina M. Henkin, Wendy Champness, 4th edition, American Society for Microbiology, Washington. 2013.
  • Principles of Genetics, (7th edition), D P Snustad and M J Simmons, John Wiley & Sons Inc., USA., 2015
  • Genetics, (3rd edition), M V Strickberger, New Delhi: PHI Learning, 2012
  • Principles of Genetics, (12th edition), E J Gardener, M J Simmons and D P Snustead, John Wiley and Sons Publications, 2012
  • Human Genetics: Concepts and Applications, (10th edition), R Lewis, WCB McGraw Hill, USA, 2011.
  • Current perspectives in Genetics. Insight and applications in Molecular, Classical and Human Genetics, S Cummings, Brooks/ Cole, 2000
  • Genetics: Principles and Analysis, (4th edition), D L Hartl and E W Jones, Jones and Barlett Publishers, Massachusetts, USA, 1998.        

 

      e RESOURCES:

 

      JOURNALS:

  • Journal of Genetics
  • Frontiers in Genetics
  • Environmental and molecular mutagenesis
  • Nature Genetics
  • Genetics Research

 

Academic Year: 
2023-2024
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