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Molecular Biology
This paper will enable students to- • understand the basic processes involved in the flow of genetic information • study the processing of the protein synthesized • understand the regulation of gene expression
DNA and Genome: The primary structure of DNA, packaging of DNA, Gene in molecular terms, physical and chemical nature of nucleic acid,types of DNA (A, B, Z).
DNA replication in prokaryotes and eukaryotes, enzymes involved in replication, DNA repair mechanism- mismatch repair, base excision repair, Nucleotide excision repair photoreactivation, Recombination and repair (Holiday model)
Transcription in prokaryotes and eukaryotes, mRNA structure (coding and non coding RNA; miRNA, siRNA and hnRNA), Ribozyme, Posttranscriptional modifications.
Genetic code, Prokaryotic and eukaryotic translation, Post translational modification of proteins and its breakdown, inhibitors of protein synthesis.
Regulation of gene expression in prokaryotes and eukaryotes at transcription and translation level, Operon concept-positive and negative regulation of lac operon, trp operon
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