NANOBIOTECHNOLOGY

Paper Code: 
MBL-227 B
Credits: 
2
Contact Hours: 
30
Objective: 

Course Outcomes (COs):

Course Outcomes

Learning and teaching strategies

Assessment Strategies

Upon completion of the course the learner will:

CO 81B: Understand various nanostructure formation

CO 82B: Design nano films and their characterization

CO 83B: Apply the nano structures for various purposes

CO 84B: Identify toxicity of nanoparticles

CO 85B: Devise methods to detect toxicity of nanoparticles

Class lectures

Seminars

Tutorials

Group discussions and Workshops

Question preparation

 

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects

 

6.00
Unit I: 
Introduction to Nano biotechnology

Introduction to Nanobiotechnology; Concepts, historical perspective; Different formats of nanomaterials and applications with example for specific cases; Cellular Nanostructures; Nanopores; Biomolecular motors; Bio-inspired Nanostructures, Synthesis and characterization of different nanomaterials.

 

4.00
Unit II: 
Nano – films

Thin films; Colloidal nanostructures; Self Assembly, Nano vesicles; Nanospheres; Nanocapsules and their characterisation.

 

8.00
Unit III: 
Nano – particles and their Applications

Nanoparticles for drug delivery, concepts, optimization of nanoparticle properties for suitability of administration through various routes of delivery, advantages, strategies for cellular internalization and long circulation, strategies for enhanced permeation through various anatomical barriers.

Nanoparticles for diagnostics and imaging (theranostics); concepts of smart stimuli responsive nanoparticles, implications in cancer therapy, nanodevices for biosensor development.

 

6.00
Unit IV: 
Nano – materials

Nanomaterials for catalysis, development and characterization of nanobiocatalysts, application of nanoscaffolds in sythesis, applications of nanobiocatalysis in the production of drugs and drug intermediates.

 

6.00
Unit V: 
Nano – toxicity

Introduction to Safety of nanomaterials, Basics of nanotoxicity, Models and assays for Nanotoxicity assessment; Fate of nanomaterials in different stratas of environment; Ecotoxicity models and assays; Life Cycle Assessment, containment.

 

 

ESSENTIAL READINGS: 
  • Gero Decher, Joseph B. Schlenoff, (2003); Multilayer Thin Films: Sequential Assembly
  • of Nanocomposite Materials, Wiley-VCH Verlag GmbH & Co. KGaA
  • David S. Goodsell, (2004); Bionanotechnology: Lessons from Nature; Wiley-Liss
  • Neelina H. Malsch (2005), Biomedical Nanotechnology, CRC Press
  • Greg T. Hermanson, (2013); Bioconjugate Techniques, (3rd Edition); Elsevier
  • Recent review papers in the area of Nanomedicine.

 

REFERENCES: 

SUGGESTED READING

  • Springer Handbook of Nanotechnology- Ed. by B. Bhushan, Springer-Verlag (2004)
  • Vacuum Technology, A. Roth, North- Holland Pub., 2nd Edition (1982)
  • The Chemistry of Nanomaterials: Synthesis, Properties and Applications, C.N.R. Rao, A.
  • Muller, A. K. Cheetham (Eds), Wiley-VCH Verlag (2004)
  • B.S. Murty and S. Ranganathan, International Materials Reviews (1998) Vol. 43(3), 101.
  • Introduction to nanoscience and nanotechnology, CRC Press, Tylor and Francis Group, Boca
  • Raton, G. L. Hornyak, H. F. Tibbals, J. Dutta and J J. Moore.
  • Introductory Nanoscience: Physical and Chemical Concepts, CRC Press, Tylor and Francis Group, Boca Raton, M. Kuno.
  • Nanochemistry: A chemical approach to Nanomaterials Ozin and Arsenault Roayal Society of Chemistry, Cambridge, UK First Edition, 2005.
  • Synthesis and Processing Techniques Naveen Kumar JagadapuraRam egowda, Shareefraza J.  Ukkund, Prasad Puthiyillam LAP Lambert Academic Publishing. ISBN: 978-6139-81532-6 First Edition, 2018.

e RESOURCES

JOURNALS

  • IET Nano biotechnology, Wiley
  • Nanomaterials and Nanotechnology, SAGE Publication
  • Nano Materials Science, Science direct

 

 

Academic Year: 
2023-2024
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