NANOBIOTECHNOLOGY

Paper Code: 
BTE 227B
Credits: 
2
Contact Hours: 
30
6.00
Unit I: 
Introduction to nanobiotechnology

Introduction to Nanobiotechnology; Concepts, historical perspective; Different formats of nanomaterials and applications with example for specific cases; Cellular Nanostructures; Nanopores; Biomolecular motors; Bio-inspired Nanostructures, Synthesis and characterization of different nanomaterials.

4.00
Unit II: 
Nano – films

Thin films; Colloidal nanostructures; Self Assembly, Nanovesicles; Nanospheres; Nanocapsules and their characterisation.

8.00
Unit III: 
Nano – particles and their Applications

Nanoparticles for drug delivery, concepts, optimization of nanoparticle properties for suitability of administration through various routes of delivery, advantages, strategies for cellular internalization and long circulation, strategies for enhanced permeation through various anatomical barriers.
Nanoparticles for diagnostics and imaging (theranostics); concepts of smart stimuli responsive nanoparticles, implications in cancer therapy, nanodevices for biosensor development.

6.00
Unit IV: 
Nano – materials

Nanomaterials for catalysis, development and characterization of nanobiocatalysts, application of nanoscaffolds in sythesis, applications of nanobiocatalysis in the production of drugs and drug intermediates.

6.00
Unit V: 
Nano – toxicity

Introduction to Safety of nanomaterials, Basics of nanotoxicity, Models and assays for Nanotoxicity assessment; Fate of nanomaterials in different stratas of environment; Ecotoxicity models and assays; Life Cycle Assessment, containment.

ESSENTIAL READINGS: 

• Gero Decher, Joseph B. Schlenoff, (2003); Multilayer Thin Films: Sequential Assembly
• of Nanocomposite Materials, Wiley-VCH Verlag GmbH & Co. KGaA
• David S. Goodsell, (2004); Bionanotechnology: Lessons from Nature; Wiley-Liss
• Neelina H. Malsch (2005), Biomedical Nanotechnology, CRC Press
• Greg T. Hermanson, (2013); Bioconjugate Techniques, (3rd Edition); Elsevier
• Recent review papers in the area of Nanomedicine.

REFERENCES: 

• Springer Handbook of Nanotechnology- Ed. by B. Bhushan, Springer-Verlag (2004)
Vacuum Technology, A. Roth, North- Holland Pub., 2nd Edition (1982)
• The Chemistry of Nanomaterials: Synthesis, Properties and Applications, C.N.R. Rao, A.
Muller, A. K. Cheetham (Eds), Wiley-VCH Verlag (2004)
• B.S. Murty and S. Ranganathan, International Materials Reviews (1998) Vol. 43(3), 101.
Introduction to nanoscience and nanotechnology, CRC Press, Tylor and Francis Group, Boca
• Raton, G. L. Hornyak, H. F. Tibbals, J. Dutta and J J. Moore. Introductory Nanoscience: Physical and Chemical Concepts, CRC Press, Tylor and Francis Group, Boca Raton, M. Kuno.
• Nanochemistry: A chemical approach to Nanomaterials Ozin and Arsenault Roayal Society of Chemistry, Cambridge, UK First Edition, 2005.
• Synthesis and Processing Techniques Naveen Kumar Jagadapura Ram egowda, Shareefraza J. Ukkund, Prasad Puthiyillam LAP Lambert Academic Publishing. ISBN: 978-6139-81532-6
First Edition, 2018.

Academic Year: 
2023-2024
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