Department Events
No Upcoming Events
Paper IV: Advanced Toxicology
Paper Code:
LSC 144 I
Credits:
4
Contact Hours:
60
12.00
Unit I:
Principles of Toxicology
- Introduction of toxicology
- Different areas of toxicology
- Toxicology and Society
- General characteristics of the Toxic Response
- Classification of Toxic Agents
- Spectrum of Undesired Effects : Allergic and Idiosyncratic reactions, Immediate versus delayed toxicity. Reversible v/s Irreversible Toxic Effects. Local v/s systemic Toxicity. Interaction of chemicals
- Characteristics of Exposure
- Dose-Response Relationship
- Variation in Toxic Responses
- Descriptive Toxicity Tests
- Toxicogenomics
12.00
Unit II:
Toxic Effects of Metals (I)
- Metal as Toxicants
- Movement of Metals in the Environment
- Mechanism of Metal Toxicity
- Metal-binding Proteins and Metal Transporters
- Pharmacology of Metals
Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Arsenic and Beryllium
12.00
Unit III:
Toxic Effects of Metals (II)
Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Cd., Pd, Cu & Fe
12.00
Unit IV:
Chelation in Metal Intoxication
- Chelating agents, Chemistry, Pharmacology and Toxicology
- Therapy; Combination therapy, Limitations
- Oxidative Stress in Metal Toxicity, Role of antioxidants
- Therapeutic Recommendations for Heavy Metal Poisoning
Nanotoxicology :
• Nanoparticles : Naturally Occurring and Anthropogenic nano-sized material
• Physico-chemical characteristics as Determinants of Biological activity.
• Human Exposure to Nano-sized Materials
• Concept of Noanotoxicology; Ecotoxicological studies, ROS Mechanisms of Nano-sized Pesticide Toxicity, Immunogenicity of nanopesticides.
12.00
Unit V:
Immunotoxicity
· The Immune System; Antigen Recognition
· Innate Immunity, Acquired Immunity
· Inflammation, Immune – Mediated Disease
· Developmental Immunology
· Methods to Assess Immunocompetence
· Immune Modulation by Metals
Xenobiotic – Induced hypersensitivity and autoimmunity with reference to metals only.
Academic Year:
