Paper IV: Cancer Biology (Advance Paper II)

Paper Code: 
LSC 144 J
Credits: 
04
Contact Hours: 
60
12.00
Unit I: 
BIOLOGY OF CANCER
 

Cell cycle and cancer, the nature and types of cancer. Cellular oncogenes and Tumor suppressor genes: DNA viruses, retroviruses, proto oncogenes, tumor suppressor genes, pRb and control of the cell cycle clock, p53 and apoptosis. Tumor immunology: immune mediated disease (hypersensitivity and autoimmunity)

 

12.00
Unit II: 
TOXICITY AT CELLULAR LEVEL AND ENZYMOLOGY INVOLVED
 

Mechanism of toxicity: toxicity of O2, xenobiotics, mutagens and carcinogens. Multistage carcinogenesis: chemical carcinogens-genotoxic, nongenotoxic and inorganic carcinogens

Biotransformation of xenobiotics through liver detoxification (Phase I and II). Mechanism of repair (molecular and cellular), toxicity resulting from inappropriate repair

 

12.00
Unit III: 
PRINCIPLES OF CANCER TREATMENT
Natural history of cancer therapy, ethical and philosophical issues

Treatment available: surgery, radiation, chemotherapy, biological therapy, gene therapy

 

12.00
Unit IV: 
PRINCIPLES OF CANCER SCREENING AND CHEMOPREVENTION OF CANCER
 

Screening of cancer and the biases of screening, screening of specific cancers

Chemoprevention: Chemopreventive agents from natural products, preclinical animal model selection, phytopharmaceuticals in cancer chemoprevention

 

12.00
Unit V: 
TEST SYSTEMS/ASSAYS USED IN CANCER
Carcinogenicity assessment: short term tests for mutagenicity, chronic testing for carcinogenicity and transgenic animals in carcinogenicity assessment

Assays for detecting genetic alterations: DNA damage and repair assays, genetic alteration in mammals, mammalian cytogenetic assays, germ cell mutagenesis

New approaches to genetic toxicology 

 

ESSENTIAL READINGS: 
  • Casarett & Doull’s (7th ed ) Toxicology: The basic Science of Poisons, Curtis D. Klassen
  • Haskell: Caner Treatment (4th Ed), W.B Saunders Company, Mc. Graw Hill.
  • Pecckham, Pinedo and Veronesi: Oxford Textbook of Oncology,Vol:1 and 2.
  • Chemoprevention of Cancer and DNA Damage by Dietary Factors: Edited by Siegfried Knasmüller, David M. DeMarini, Ian Johnson, and Clarissa Gerhäuser. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Academic Year: 
2020-2021
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