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Semester IV B.Sc. (Pass Course) - Biotechnology (2016-17)
This paper will enable students to- • learn the fundamentals of immune system • study the various cellular and molecular aspects of immune system • understand the regulation of immune response • learn various immunological diagnostic techniques
Introduction to immune system- Innate and acquired immunity
Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells. Structure and function of lymphoid organs
Nature and biology of antigens and super antigens Immunoglobulin: structure, types and their function MHC, B and T-Cell Receptor Complement system
Generation of Humoral and Cell mediated immune responses B- and T- cell maturation, activation and differentiation Cytokines and their role in immune regulation T-cell regulation, MHC restriction Immunological tolerance
Antigen processing and presentation Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence
Hypersenstivity
Autoimmunity
Vaccine Types: RD vaccines, Peptides, Proteins, DNA
AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)
1. Kuby Immunology, R.A. Goldsby and others, 4th edition, Freeman & Co., New York, 2001 2. Roitt’s Essential Immunology, Ivan M .Roitt and Peter J. Delves, 10th edition, Blackwell Science, 2001 3. Instant Notes on Immunology, Lydyard, Wheran and Fanger, 2nd edition, Viva Books Pvt. Ltd., 2003
1. Cellular and Molecular Immunology, Abbas, Litchman and Pober, 3rd edition, Harcourt Brace and Company, 1998 2. Immunology: A Comprehensive, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001 3. Medical Microbiology and Immunology: Examination and Board Review by Warren Levinson and Ernst Jawetz, 7th edition, Mc Graw Hill, 2002
