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Genetics
Course Objectives:
This course will enable the students to -
- Study the classical genetics & gene interactions.
- Learn the mechanism of sex linked inheritance and sex determination.
- Understand concept of gene, linkage, crossing over& recombination mechanisms.
- Understand gene mutations and chromosomal aberrations.
- Learn about extracytoplasmic inheritance & population genetics.
Course Outcomes (COs):
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Course |
Learning outcome (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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BTE 221
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Genetics
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Upon completion of the course students will be able to: CO 28: Assess classical genetics CO 29: Analyze mechanism of sex determination and sex-linked inheritance CO 30: Evaluate concept of gene and recombination mechanisms CO 31: Compare and contrast gene mutations and chromosomal aberrations CO 32: Assess extracytoplasmic inheritance and population genetics |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments Learning activities for the students: Self learning assignments, Effective questions, Giving tasks |
Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation |
Mendel's experiments Monohybrid ratios-Dominance and Recessive factors Laws of segregation - Dihybrid and Tri hybrid ratios - Laws of independent assortments - Test cross and Back cross. Allelic and non-allelic interactions.
• Inheritance of quantitative traits-additive effect-skin color in man
• Mechanism of Sex determination in Drosophila, Birds, Man, hymenopterans, environmental factors & sex determination.
• X-linked inheritance, pattern of inheritance of sex linked genes, sex linkage in • Drosophila, X-linked traits in humans.
Gene: unit of structure & function, complementation test.
• Linkage & crossing over. Conjugation, transformation & transduction in bacteria and their use in preparation of genetics maps.
Molecular basis of mutation, spontaneous & induced mutations, chemical and physical mutagens, Ames test.
• DNA repair mechanisms- photo reactivation, excision repair, mismatch repair, recombination repair, and SOS response. Repair defects & human diseases.
• Chromosomal aberrations- changes in chromosome structure & number, inherited disorders.
Cytoplasmic organelles & symbionts, DNA in mitochondria & chloroplast, cytoplasmic male sterility in plants, maternal effects.
• Population Genetics: Genetic variation, Random mating, Genetic frequency and Hardy-Weinberg law.
