Immunology

Paper Code: 
MBL 401
Credits: 
03
Contact Hours: 
45
Objective: 

This paper will enable students to:

  • learn the fundamentals of immune system
  • study the various cellular and molecular aspects of immune system
  •  understand the regulation of immune response
  •  learn various immunological diagnostic techniques

 

8.00
Unit I: 
Basic Immunology

Introduction to immune system- Innate and acquired immunity

Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells. Structure and function of lymphoid organs

11.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens Immunoglobulin: structure, types and their function MHC, B and T-Cell Receptor Complement system

10.00
Unit III: 
Immune response and its regulation

Generation of Humoral and Cell mediated immune responses-B- and T- cell maturation, activation and differentiation.Cytokines and their role in immune regulation .T-cell regulation, MHC restriction.Immunological tolerance

7.00
Unit IV: 
Antigen- antibody interactions

Antigen processing and presentation Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

9.00
Unit V: 
Selected concepts in Immunology

Hypersenstivity

Autoimmunity

Vaccine Types: RD vaccines, Peptides, Proteins, DNA

AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)

ESSENTIAL READINGS: 
  1. Kuby Immunology, 4th edition- R.A. Goldsby and others, Freeman & Co., New York, 2001
  2.  Roitt’s, Essential Immunology, 10th edition, Ivan M Roitt and Peter J Delves, Blackwell Science, 2001
  3.  Instant Notes on Immunology, 2nd edition, Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003
     
REFERENCES: 
  1. Cellular and Molecular Immunology, 3rd edition, Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
  2. Immunology: A Comprehensive Review, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  3. Medical Microbiology and Immunology: Examination and Board Review, 7th edition,Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002
     
Academic Year: 
2018-2019
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