IMMUNOLOGY

Paper Code: 
MBL 223
Credits: 
5
Contact Hours: 
75
Objective: 

Course Outcomes (COs):

               Course Outcomes

Learning and teaching strategies

Assessment Strategies

  
 

Upon completion of the course the learner will:

CO 52:  Understand the role of different cells and organs in immunology.

CO 53: Classify and compare the molecules of immunity (antibodies, MHC, B- and T-cell receptors, cytokines).

CO 54: Explain the mechanism of generation of immune response and its regulation.

CO 55: Interpret and compare the type of immune response generated against a specific infection (viral or bacterial).

CO 56: Understand the antigen-antibody interactions and utilize them for detecting immunological disorders.

Interactive Lectures,

Discussion,

Tutorials,

Demonstrations,

Assignments

Reading Journals

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects

  

 

15.00
Unit I: 
Introduction to immune system
  • History of Immunology
  • Innate and acquired immunity, Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells.
  • Organization, structure and function of lymphoid organs 
15.00
Unit II: 
Cellular and molecular aspects
  • Nature and biology of antigens and super antigens
  • Immunoglobulin: structure, types and their function
  • HLA typing and Major histocompatibility complex
  • T-Cell Receptors: Generation and diversity
  • Complement system    

                            

15.00
Unit III: 
Immune response & its regulation
  • Antigen processing and presentation
  • Generation of Humoral and Cell mediated immune responses: B- and T- cell maturation (MHC restriction, Immunological tolerance), activation and differentiation, T-cell regulation
  • Cytokines and their role in immune regulation
  • Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity
15.00
Unit IV: 
Antigen- antibody interactions

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, Immunofluorescence microscopy and flow cytometry, ELISA, ELISPOT Assay, lymphoproliferation assay, mixed lymphocyte reaction

15.00
Unit V: 
Advanced concepts in Immunology
  • Hypersensitivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity against infectious agents (intracellular parasites, helminthes and viruses), Tumor Immunology, AIDS and other immune-deficiencies, Monoclonal antibodies: Hybridoma Technology, Phage Display, Huminized Antibodies
ESSENTIAL READINGS: 
  • Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York, 2018.
  • Roitt’s Essential Immunology, (13th edition), Ivan M. Roitt and Peter J. Delves, Blackwell Science, 2017
  • Instant Notes on Immunology, (3rd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011

 

REFERENCES: 

SUGGESTED READINGS:

·         Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017

·         Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002

·         Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004

 

e RESOURCES:

·  National Health Mission Immunization :: National Health Mission (nhm.gov.in)

·  Lymphocyte proliferation assay Lymphocyte Proliferation Assay (hanc.info)

·         Stella C. Knight, Penelope A. Bedford, Andrew J. Stagg, Chapter 30 - Mixed Leukocyte Reactions, Editor(s): Michael T. Lotze, Angus W. Thomson, Measuring Immunity, Academic Press, 2005, Pages 350-360, ISBN 9780124559004, https://doi.org/10.1016/B978-012455900-4/50292-0.

Journals:

·         Cancer Immunology, Immunotherapy Cancer Immunology, Immunotherapy | Home (springer.com)

·         Cellular and Molecular Immunology Cellular & Molecular Immunology (nature.com)

·         Clinical Microbiology Reviews Clinical Microbiology Reviews Journal Homepage (asm.org)

·         Immunity, inflammation and disease Immunity, Inflammation and Disease - Wiley Online Library

          Immunology Letters Immunology Letters | Journal | ScienceDirect.com by Elsevier

Academic Year: 
2022-2023
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