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Immunology (Theory)
This course will enable the students to learn about structural and functional features of components of immune system. The major emphasis of this course will be on development of immune system and mechanisms by which our body elicits immune response. This will be imperative for students as it will help them to predict about nature of immune response that develops against bacterial, viral or parasitic infection, and prove it by designing new experiments.
History of Immunology
Innate and acquired immunity
Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells.
Organization, structure, and function of lymphoid organs
Nature and biology of antigens and super antigens
Immunoglobulin: structure, types and their function
HLA typing and Major histocompatibility complex
T-Cell Receptors: Generation and diversity
Complement system
Antigen processing and presentation
Generation of Humoral and Cell mediated immune responses: B- and T- cell maturation (MHC restriction, Immunological tolerance), activation and differentiation, T-cell regulation
Cytokines and their role in immune regulation
Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity
Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, Immunofluorescence microscopy and flow cytometry, ELISA, ELISPOT Assay, lymphoproliferation assay, mixed lymphocyte reaction.
Hypersensitivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity against infectious agents (intracellular parasites, helminthes and viruses), Tumor immunology, AIDS and other immune-deficiencies, Monoclonal antibodies: Hybridoma Technology, Phage display, Humanized antibody.
- Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A. Osbarne, (Freeman) & Co. New York, 2018.
- Roitt’s Essential Immunology, (13th edition), Ivan M. Roitt and Peter J. Delves, Blackwell Science, 2017
- Instant Notes on Immunology, (3rd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011
SUGGESTED READINGS:
- Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017
- Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002
- Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004
e RESOURCES:
- National Health Mission Immunization :: National Health Mission (nhm.gov.in)
- Lymphocyte proliferation assay Lymphocyte Proliferation Assay (hanc.info)
- Stella C. Knight, Penelope A. Bedford, Andrew J. Stagg, Chapter 30 - Mixed Leukocyte Reactions, Editor(s): Michael T. Lotze, Angus W. Thomson, Measuring Immunity, Academic Press, 2005, Pages 350-360, ISBN 9780124559004, https://doi.org/10.1016/B978-012455900-4/50292-0.
JOURNALS:
- Cancer Immunology, Immunotherapy Cancer Immunology, Immunotherapy | Home (springer.com)
- Cellular and Molecular Immunology Cellular & Molecular Immunology (nature.com)
- Clinical Microbiology Reviews Clinical Microbiology Reviews Journal Homepage (asm.org)
- Immunity, inflammation and disease Immunity, Inflammation and Disease - Wiley Online Library
- Immunology Letters Immunology Letters | Journal | ScienceDirect.com by Elsevier
