Paper IV: Advanced Toxicology

Paper Code: 
LSC 144 I
Credits: 
4
Contact Hours: 
60
12.00
Unit I: 
Principles of Toxicology
  • Introduction of toxicology
  • Different areas of toxicology
  • Toxicology and Society
  • General characteristics of the Toxic Response
  • Classification of Toxic Agents
  • Spectrum of Undesired Effects : Allergic and Idiosyncratic reactions, Immediate versus delayed toxicity. Reversible v/s Irreversible Toxic Effects. Local v/s systemic Toxicity. Interaction of chemicals
  • Characteristics of Exposure
  • Dose-Response Relationship
  • Variation in Toxic Responses
  • Descriptive Toxicity Tests
  • Toxicogenomics
12.00
Unit II: 
Toxic Effects of Metals (I)
  • Metal as Toxicants
  • Movement of Metals in the Environment
  • Mechanism of Metal Toxicity
  • Metal-binding Proteins and Metal Transporters
  • Pharmacology of Metals

Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Arsenic and Beryllium 

12.00
Unit III: 
Toxic Effects of Metals (II)

Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Cd., Pd, Cu & Fe

12.00
Unit IV: 
Chelation in Metal Intoxication
  • Chelating agents, Chemistry, Pharmacology and Toxicology
  • Therapy; Combination therapy, Limitations
  • Oxidative Stress in Metal Toxicity, Role of antioxidants
  • Therapeutic Recommendations for Heavy Metal Poisoning
Nanotoxicology :
 
• Nanoparticles : Naturally Occurring and Anthropogenic nano-sized material
• Physico-chemical characteristics as Determinants of Biological activity.   
• Human Exposure to Nano-sized Materials 
• Concept of Noanotoxicology; Ecotoxicological studies, ROS Mechanisms of Nano-sized Pesticide Toxicity, Immunogenicity of nanopesticides. 
 
12.00
Unit V: 
Immunotoxicity

·         The Immune System; Antigen Recognition

·         Innate Immunity, Acquired Immunity

·         Inflammation, Immune – Mediated Disease

·         Developmental Immunology

·         Methods to Assess Immunocompetence

·         Immune Modulation by Metals

Xenobiotic – Induced hypersensitivity and autoimmunity with reference to metals only.

Academic Year: 
2018-2019
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