IMMUNOLOGY

Paper Code: 
MBL 401
Credits: 
03
Contact Hours: 
45
Objective: 

 This paper will enable students to understand –

 

  1. The nature of biological material and hierarchy of molecular organization of cells.
  2. The thermodynamic principles underlying biochemical reactions and the function of macromolecules.
  3. The students will learn the concept of enzyme catalysis, reaction mechanism and regulation of enzyme activity

Course Outcomes (COs):

 

Course

Learning outcome (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

MBL 401

Immunology

CO 1 lLearn the fundamentals of immune system

CO 2 Study the various cellular and molecular aspects of immune system

CO 3 Understand the regulation of immune response

CO 4 Understand the role of different types of Cells, Effector Molecules and Effector Mechanisms in Immunology.

CO 5 Understand the principles underlying various Immunotechniques.

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, presentations

 

Learning activities for the students:

Self-learning assignments, Effective questions, Seminar presentation, Giving tasks.

 

C A test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Classroom interaction

 

8.00
Unit I: 
Basic Immunology

             

Introduction to immune system- Innate and acquired immunity

Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils and Mast Cells. Structure and function of lymphoid organs

 

11.00
Unit II: 
Cellular and molecular aspects

                      

Nature and biology of antigens and super antigens

Immunoglobulin: structure, types and their function

MHC, B and T-Cell Receptor

Complement system

 

 

10.00
Unit III: 
Immune response & its regulation

                         

Generation of Humoral and Cell mediated immune responses

B-and T- cell maturation, activation and differentiatio

Cytokines and their role in immune regulation

T-cell regulation, MHC restriction

Immunological tolerance

7.00
Unit IV: 
Antigen- antibody interactions

                                                            

Antigen processing and presentation

Precipitation, Immunodiffusion, Immunoelectrophoresis, Agglutination, RIA, ELISA, Immunofluorescence

9.00
Unit V: 
Selected concepts in Immunology

                                      

Hypersenstivity

Autoimmunity

Vaccine Types: RD vaccines, Peptides, Proteins, DNA

AIDS and other immunodeficiencies (SCID, DiGeorge syndrome, Chediak- Higashi syndrome)

ESSENTIAL READINGS: 
  1. Kuby Immunology, 4th edition- R.A. Goldsby and others, Freeman & Co., New York, 2001
  2. Roitt’s, Essential Immunology, 10th edition, Ivan M Roitt and Peter J Delves, Blackwell Science, 2001
  3. Instant Notes on Immunology, 2nd edition, Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2003

 

REFERENCES: 
  1. Cellular and Molecular Immunology, 3rd edition, Abbas, Litchman and Pober, Harcourt Brace and Company, 1998
  2. Immunology: A Comprehensive Review, Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2001
  3. Medical Microbiology and Immunology: Examination and Board Review, 7th edition, Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2002

 

Academic Year: 
2020-2021
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