Immunology

Paper Code: 
CMBL 401
Credits: 
04
Contact Hours: 
60
Objective: 

 Course Outcomes (COs):

       Course Outcomes

Learning and teaching strategies

Assessment Strategies

  
 

Upon completion of the course the learner will:

CO 30:  Understand the role of

different cells and organs in immunology.

CO 31: Classify and compare the molecules of immunity (antibodies,

MHC, B- and T-cell receptors, cytokines).

CO 32: Explain the mechanism of generation of immune response and its regulation.

CO 33: Interpret and compare the type of immune response generated against a specific infection (viral or bacterial).

CO 34: Understand the antigen-antibody interactions and utilize them for detecting immunological disorders.

Interactive Lectures,

Discussion,

Tutorials,

Demonstrations,

Assignments

Reading Journals

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects

  

 

12.00
Unit I: 
Introduction to immune system

History of Immunology

Innate and acquired immunity

Cells of the Immune system: Hematopoiesis and differentiation, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Dendritic cells, NK cells, Eosinophils, Neutrophils, Basophils, and Mast Cells.

Organization, structure, and function of lymphoid organs

 

12.00
Unit II: 
Cellular and molecular aspects

Nature and biology of antigens and super antigens

Immunoglobulin: structure, types and their function

HLA typing and Major histocompatibility complex

T-Cell Receptors: Generation and diversity

Complement system           

12.00
Unit III: 
Immune response & its regulation

Antigen processing and presentation

Generation of Humoral and Cell mediated immune responses: B- and T- cell maturation (MHC restriction, Immunological tolerance), activation and differentiation, T-cell regulation

Cytokines and their role in immune regulation

Cell-mediated cytotoxicity: Mechanism of T cell and NK cell mediated lysis, Antibody dependent cell mediated cytotoxicity, and macrophage mediated cytotoxicity

 

12.00
Unit IV: 
Antigen- antibody interactions
12.00
Unit V: 
Advanced concepts in Immunology

Hypersensitivity, Autoimmunity, Vaccine development and immunization programme, Transplantation, Immunity against infectious agents (intracellular parasites, helminthes and viruses), Tumor immunology, AIDS and other immune-deficiencies, Monoclonal antibodies: Hybridoma Technology, Phage display, Humanized antibodies

 

ESSENTIAL READINGS: 
  • Kuby’s Immunology, (8th Edition)-R.A. Goldsby, Thomas J. Kindr. Barbara, A.     Osbarne, (Freeman) & Co. New York, 2018.
  • Roitt’s Essential Immunology, (13th edition), Ivan M. Roitt and Peter J. Delves,     Blackwell Science, 2017
  • Instant Notes on Immunology, (3rd edition), Lydyard, Wheran and Fanger, Viva Books Pvt. Ltd., 2011

 

REFERENCES: 

SUGGESTED READINGS:

  • Cellular and Molecular Immunology, (10th edition), Abbas, Litchman and Pober, Harcourt Brace and Company, 2017
  • Immunology: A Comprehensive Review. Darla J. Wise and Gordon R. Carter, Iowa State University Press, 2002
  • Medical Microbiology and Immunology: Examination and Board Review, (8th edition), Warren Levinson and Ernst Jawetz, Mc Graw Hill, 2004

 

e RESOURCES:

JOURNALS:

 

Academic Year: 
2023-2024
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